Smc5/6, an atypical SMC complex with two RING-type subunits
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Smc5/6, an atypical SMC complex with two RING-type subunits Roger Solé-Soler ; Jordi Torres-Rosell Crossmark: Check for Updates Biochem Soc Trans (2020) 48 (5): 2159-2171. https://doi.org/10.1042/BST20200389 Article history Share Icon Share Cite Icon Cite Get Permissions The Smc5/6 complex plays essential roles in chromosome segregation and repair, by promoting disjunction of sister chromatids. The core of the complex is constituted by an heterodimer of Structural Maintenance of Chromosomes (SMC) proteins that use ATP hydrolysis to dynamically associate with and organize chromosomes. In addition, the Smc5/6 complex contains six non-SMC subunits. Remarkably, and differently to other SMC complexes, the Nse1 and Nse2 subunits contain RING-type domains typically found in E3 ligases, pointing to the capacity to regulate other proteins and complexes through ubiquitin-like modifiers. Nse2 codes for a C-terminal SP-RING domain with SUMO ligase activity, assisting Smc5/6 functions in chromosome segregation through sumoylation of several chromosome-associated proteins. Nse1 codes for a C-terminal NH-RING domain and, although it has been proposed to have ubiquitin ligase activity, no Smc5/6-dependent ubiquitylation target has been described to date. Here, we review the function of the two RING domains of the Smc5/6 complex in the broader context of SMC complexes as global chromosome organizers of the genome.
Is part ofBiochemical Society Transactions, 2020, vol. 48, num. 5, p. 2159-2171
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Zapatka, Mariel; Pociño Merino, Irene; Heluani-Gahete, Hayat; Bermúdez López, Marcelino; Tarrés, Marc; Ibars Estiarte, Eva Irene; Solé-Soler, Roger; Gutiérrez-Escribano, Pilar; Apostolova, Sonia; Casas Herranz, Celia; Aragon, Luis; Wellinger, Ralf Erik; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Elsevier, 2019)Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential ...
Gutierrez Escribano, Pilar; Hormeño, Silvia; Madariaga Marcos, Julene; Solé Soler, Roger; O'Reilly, Francis J.; Morris, Kyle; Aicart Ramos, Clara; Aramayo, Ricardo; Montoya, Alex; Kramer, Holger; Rappsilber, Juri; Torres Rosell, Jordi; Moreno Herrero, Fernando; Aragon, Luis (Elsevier, 2020-12-17)Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power a plethora of functions requiring organization and restructuring of eukaryotic chromosomes in interphase and during mitosis. The Smc5/6 ...
Bermúdez López, Marcelino; Ceschia, Audrey; Piccoli, Giacomo De; Colomina i Gabarrella, Neus; Pasero, Philippe; Aragón, Luis; Torres Rosell, Jordi (Oxford University Press, 2010)Mitotic chromosome segregation requires the removal of physical connections between sister chromatids. In addition to cohesin and topological entrapments, sister chromatid separation can be prevented by the presence of ...