Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only

Thumbnail
View/Open
Issue date
2021-01-11
Author
Miguel, Ricardo de
Asín, Javier
Rodríguez-Largo, Ana
Echeverría, Irache
Lacasta, Delia
Pinczowski, Pedro
Gimeno, Marina
Molín, Jéssica
Fernández, Antonio
Blas, Ignacio de
Andrés, Damián de
Pérez, Marta
Reina, Ramsés
Luján, Lluís
Suggested citation
Miguel, Ricardo de; Asín, Javier; Rodríguez-Largo, Ana; Echeverría, Irache; Lacasta, Delia; Pinczowski, Pedro; ... Luján, Lluís. (2021) . Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only. Animals, 2021, vol. 11, núm. 1, p. 146. https://doi.org/10.3390/ani11010146.
Impact

Google Scholar logo  Google Scholar
Share
Export to Mendeley
Metadata
Show full item record
Abstract
Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep—the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.
URI
http://hdl.handle.net/10459.1/70480
DOI
https://doi.org/10.3390/ani11010146
Is part of
Animals, 2021, vol. 11, núm. 1, p. 146
Collections
cc-by, (c) Miguel, Ricardo de et al., 2021
Except where otherwise noted, this item's license is described as cc-by, (c) Miguel, Ricardo de et al., 2021