Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only

View/ Open
Issue date
2021-01-11Author
Miguel, Ricardo de
Asín, Javier
Rodríguez-Largo, Ana
Echeverría, Irache
Lacasta, Delia
Pinczowski, Pedro
Gimeno, Marina
Molín, Jéssica
Fernández, Antonio
Blas, Ignacio de
Andrés, Damián de
Pérez, Marta
Reina, Ramsés
Luján, Lluís
Suggested citation
Miguel, Ricardo de;
Asín, Javier;
Rodríguez-Largo, Ana;
Echeverría, Irache;
Lacasta, Delia;
Pinczowski, Pedro;
...
Luján, Lluís.
(2021)
.
Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only.
Animals, 2021, vol. 11, núm. 1, p. 146.
https://doi.org/10.3390/ani11010146.
Metadata
Show full item recordAbstract
Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep—the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.