Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only

View/ Open
Issue date
2021-01-11Author
Miguel, Ricardo de
Asín, Javier
Rodríguez-Largo, Ana
Echeverría, Irache
Lacasta, Delia
Pinczowski, Pedro
Gimeno, Marina
Molín, Jéssica
Fernández, Antonio
Blas, Ignacio de
Andrés, Damián de
Pérez, Marta
Reina, Ramsés
Luján, Lluís
Suggested citation
Miguel, Ricardo de;
Asín, Javier;
Rodríguez-Largo, Ana;
Echeverría, Irache;
Lacasta, Delia;
Pinczowski, Pedro;
...
Luján, Lluís.
(2021)
.
Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only.
Animals, 2021, vol. 11, núm. 1, p. 146.
https://doi.org/10.3390/ani11010146.
Metadata
Show full item recordAbstract
Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep—the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.
Is part of
Animals, 2021, vol. 11, núm. 1, p. 146European research projects
Collections
Except where otherwise noted, this item's license is described as cc-by, (c) Miguel, Ricardo de et al., 2021
Related items
Showing items related by title, author, creator and subject.
-
Spanish Consensus Statement: Clinical Management and Treatment of Tendinopathies in Sport
Fernandez Jaén, Tomas; Álvarez Rey, Guillermo; Angulo, Francisco; Ardevol Cuesta, Jordi; Arriaza Loureda, Rafael; Ávila España, Fernando; Ayala, Juan; Balius Matas, Ramón; Baró Pazos, Fernando; Dios Beas Jiménez, Juan de; Candel Rosell, Jorge; Cobián Fernandez, César; Doñoro Cuevas, Mª del Pilar; Esparza Ros, Francisco; Espejo Colmenero, Josefina; Fernández de Prado, Jorge; García Cota, Juan José; Garrido González, Jose Ignacio; Gonzalez de Vega, Carlos; González Santander, Manuela; Herrador Munilla, Miguel Ángel; Ivorra Ruiz, Francisco; Jiménez Díaz, Fernando; Maestro Fernandez, Antonio; Manonelles Marqueta, Pedro; Muñoz Benito, Juan Jose; Olivé Vilás, Ramón; Pedret, Carles; Peirau i Terés, Xavier; Peña Amaro, José; Puigdellivoll Grifell, Jordi; Pérez San Roque, Juan; Ramírez Parenteu, Christophe; Ribas Serna, Juan; Rodas, Gil; Sánchez Álvarez, Mikel; Sanchez Marchori, Carlos; Til Perez, Lluis; Ureña Durán, Rosario; Valle Soto, Miguel de; Villalón Alonso, José María; Guillen García, Pedro; Spanish Group for Tendon Consensus (Sage, 2017)On October 15, 2016, experts met at Clínica CEMTRO in Madrid, Spain, under the patronage of the Spanish Society for Sports Traumatology (SETRADE), the Spanish Society of Sports Medicine (SEMED), the Spanish Association of ... -
Relationship of Weather Types on the Seasonal and Spatial Variability of Rainfall, Runoff, and Sediment Yield in the Western Mediterranean Basin
Peña-Angulo, Dhais; Nadal-Romero, E.; González-Hidalgo, José Carlos; Albaladejo, J.; Andreu, V.; Bahri, H.; Bernal, S.; Biddoccu, M.; Bienes, Ramón; Campo, J.; Campo-Bescós, M.A.; Canatário-Duarte, A.; Cantón, Y.; Casalí Sarasibar, Javier; Castillo, Víctor; Cavallo, Eugenio; Cerdà, Artemio; Cid, Patricio; Cortesi, N.; Desir, Gloria; Díaz-Pereira, E.; Espigares, Tiscar; Estrany, Joan; Farguell Pérez, Joaquim; Fernández-Raga, M.; Ferreira, C.S.S.; Ferro, Vito; Gallart, Francesc; Giménez, R.; Gimeno, E.; Gómez, J. A.; Gómez-Gutiérrez, A.; Gómez Macpherson, Helena; González-Pelayo, O.; Kairis, O.; Karatzas, G.P.; Keesstra, Saskia; Klotz, S.; Kosmas, C.; Lana-Renault, N.; Lasanta, Teodoro; Latron, J.; Lázaro, R.; Le Bissonnais, Yves; Le Bouteiller, C.; Licciardello, F.; López Tarazón, José Andrés; Lucía, A.; Marín-Moreno, V.M.; Marín, C.; Marqués, M.J.; Martínez Fernández, José; Martínez-Mena, M.; Mateos, Luciano; Mathys, Nicole; Merino-Martín, L.; Moreno-de-las-Heras, Mariano; Moustakas, N.; Nicolau, J.M.; Pampalone, V.; Raclot, D.; Rodríguez-Blanco, M.L.; Rodrigo Comino, Jesús; Romero Díaz, María Asunción; Ruiz Sinoga, José Damián; Rubio, J.L.; Schnabel, Susanne; Senciales González, José María; Solé-Benet, A.; Taguas, E.V.; Taboada Castro, Ma. Teresa; Taboada-Castro, M.M.; Todisco, F.; Úbeda, Xavier; Varouchakis, E.A.; Wittenberg, L.; Zabaleta, A.; Zorn, Matija (MDPI, 2020-06-09)Rainfall is the key factor to understand soil erosion processes, mechanisms, and rates. Most research was conducted to determine rainfall characteristics and their relationship with soil erosion (erosivity) but there is ... -
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors
Landa, Iñigo; Ruiz-Llorente, Sergio; Montero-Conde, Cristina; Inglada-Pérez, Lucía; Schiavi, Francesca; Leskelä, Susanna; Pita, Guillermo; Milne, Roger; Maravall Royo, Javier; Ramos, Ignacio; Andía, Víctor; Rodríguez-Poyo, Paloma; Jara-Albarrán, Antonino; Meoro, Amparo; Peso, Cristina del; Arribas, Luis; Iglesias, Pedro; Caballero, Javier; Serrano, Joaquín; Picó, Antonio; Pomares, Francisco; Giménez, Gabriel; López-Mondéjar, Pedro; Castello, Roberto; Merante-Boschin, Isabella; Pelizzo, Maria-Rosa; Mauricio Puente, Dídac; Opocher, Giuseppe; Rodríguez-Antona, Cristina; González- Neira, Anna; Matias-Guiu, Xavier; Santisteban, Pilar; Robledo, Mercedes (Public Library of Science, 2009)In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and ...