The present study was designed to establish possible relationships between early fetal loss and cross-breed pregnancies. Data derived from 625 pregnant lactating dairy cows from a single herd. Pregnancy diagnosis (PD) was performed by ultrasonography at day 28 after AI. Corpus luteum and embryo number were also recorded at this time. Cows with viable embryo/s were included in the study and a second PD by palpation per rectum was performed on day 90. Early fetal loss was registered when second diagnosis proved negative. Data were analysed using logistic regression methods. Breed was not a factor affecting early fetal loss. Four-hundred nine cows were inseminated by bulls from Holstein-Friesian breed and 32 (7,8%) suffered early fetal loss; 216 were inseminated by bulls from beef breeds (BBB, Limousin and Charolais) and 14 (6,5%) were registered with early fetal loss. However, three individual bulls (two Holstein-Friesian and one BBB) were increasing the risk of early fetal loss (P<0.05). An interaction between high production (>40 l milk at PD) and twin pregnancies was also found (P=0.033), meaning that cows with single pregnancy and low milk production had 2,1 times less risk of early fetal loss than the remaining of cows.