The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity

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2020-11-01Author
Pradas Barriga, Irene
Martin-Gari, Meritxell
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Jové Font, Mariona;
Mota Martorell, Natàlia;
Pradas Barriga, Irene;
Martin-Gari, Meritxell;
Ayala Jové, Ma. Victoria (Maria Victoria);
Pamplona Gras, Reinald;
.
(2020)
.
The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity.
Antioxidants, 2020, vol. 9, num. 11, p. e1132 (1-20).
https://doi.org/10.3390/antiox9111132.
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The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups
leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological
membranes and the intracellular oxidative conditions are the main factors that modulate MDALys
formation. The low concentration of this modification in the different cellular components, found in a
wide diversity of tissues and animal species, is indicative of the presence of a complex network of
cellular protection mechanisms that avoid its cytotoxic effects. In this review, we will focus on the
chemistry of this lipoxidation-derived protein modification, the specificity of MDALys formation in
proteins, the methodology used for its detection and quantification, the MDA-lipoxidized proteome,
the metabolism of MDA-modified proteins, and the detrimental effects of this protein modification.
We also propose that MDALys is an indicator of the rate of aging based on findings which demonstrate
that (i) MDALys accumulates in tissues with age, (ii) the lower the concentration of MDALys the
greater the longevity of the animal species, and (iii) its concentration is attenuated by anti-aging
nutritional and pharmacological interventions