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dc.contributor.authorSolé Mòdol, Emma
dc.contributor.authorRos Freixedes, Roger
dc.contributor.authorTor i Naudí, Marc
dc.contributor.authorReixach, Josep
dc.contributor.authorPena i Subirà, Ramona Natacha
dc.contributor.authorEstany Illa, Joan
dc.date.accessioned2021-02-01T10:32:44Z
dc.date.available2021-02-01T10:32:44Z
dc.date.issued2021-01-28
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/70373
dc.description.abstractMaternal effects on offspring growth can impact survival and evolution of natural and domesticated populations. Genetic correlation estimates often support a negative relationship between direct and maternal effects. However, the genetic underpinnings whereby this antagonism operates are unclear. In pigs, sow feeding status and body composition condition piglet development and growth. We hypothesized that variants in genes impacting these traits may be causative of maternal influences that could be antagonistic to the direct effects for piglet growth. A recessive missense mutation (C>T) in the porcine leptin receptor (LEPR) gene (rs709596309) has been identified as the possible causal polymorphism for increased feed intake and fatness. Using data from a Duroc line, we show that the TT sows exerted a negative impact on the body weight of their offspring at the end of the growing period of similar extent to the positive direct effect of the TT genotype over each individual. Thus, TT pigs from TT dams were about as heavy as CC and CT (C-) pigs from C-dams, but TT pigs from C-dams were around 5% heavier than C-pigs from TT dams. In contrast, body composition was only influenced by LEPR direct effects. This antagonism is due to a higher propensity of TT pigs for self-maintenance rather than for offspring investment. We show that TT pigs consumed more feed, favored fatty acid uptake over release, and produced lighter piglets at weaning than their C-counterparts. We conclude that LEPR underlies a transgenerational mechanism for energy distribution that allocates resources to the sow or the offspring according to whether selective pressure is exerted before or after weaning.
dc.description.sponsorshipThe authors acknowledge the financial support from the Spanish Ministry of Science, Innovation and Universities and European Union Regional Development Funds (grants AGL2015–65846-R and RTI2018-101346-B-I00; https://www.ciencia.gob.es) and Selección Batallé (https://www.batalle.com).
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relationMINECO/PN2013-2016/AGL2015–65846-R
dc.relationMINECO/PN2013-2016/RTI2018-101346-B-I00
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0246198
dc.relation.ispartofPlos One, 2021, vol. 16, num. 1, p. e0246198
dc.relation.isreferencedbyhttp://hdl.handle.net/10459.1/69584
dc.rightscc-by (c) Solé Mòdol, Emma et al., 2021
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEnergy balance
dc.subjectFatness
dc.subjectFree fatty acids
dc.subjectLitter size
dc.subjectMilk
dc.titleAntagonistic maternal and direct effects of the leptin receptor gene on body weight in pigs
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2021-02-01T10:32:45Z
dc.identifier.idgrec030973
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0246198


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cc-by (c) Solé Mòdol, Emma et al., 2021
Except where otherwise noted, this item's license is described as cc-by (c) Solé Mòdol, Emma et al., 2021