Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative
Data de publicació2020-11-20
Boada, Luis D.
Cequier Manciñeiras, Enrique
Esteban López, Marta
Haug, Line S.
Koch, Holger M.
Pérez Luzardo, Octavio Luis
MetadadesMostra el registre d'unitat complet
The major purpose of human biomonitoring is the mapping and assessment of human exposure to chemicals. The European initiative HBM4EU has prioritized seven substance groups and two metals relevant for human exposure: Phthalates and substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- and polyfluoroalkyl substances (PFASs), halogenated and organophosphorous flame retardants (HFRs and OPFRs), polycyclic aromatic hydrocarbons (PAHs), arylamines, cadmium and chromium. As a first step towards comparable European-wide data, the most suitable biomarkers, human matrices and analytical methods for each substance group or metal were selected from the scientific literature, based on a set of selection criteria. The biomarkers included parent compounds of PFASs and HFRs in serum, of bisphenols and arylamines in urine, metabolites of phthalates, DINCH, OPFRs and PAHs in urine as well as metals in blood and urine, with a preference to measure Cr in erythrocytes representing Cr (VI) exposure. High performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was the method of choice for bisphenols, PFASs, the HFR hexabromocyclododecane (HBCDD), phenolic HFRs as well as the metabolites of phthalates, DINCH, OPFRs and PAHs in urine. Gas chromatographic (GC) methods were selected for the remaining compounds, e.g. GC-low resolution MS with electron capture negative ionization (ECNI) for HFRs. Both GC–MS and LC-MS/MS were suitable for arylamines. New developments towards increased applications of GC–MS/MS may offer alternatives to GC–MS or LC-MS/MS approaches, e.g. for bisphenols. The metals were best determined by inductively coupled plasma (ICP)-MS, with the particular challenge of avoiding interferences in the Cd determination in urine. The evaluation process revealed research needs towards higher sensitivity and non-invasive sampling as well as a need for more stringent quality assurance/quality control applications and assessments.
És part deEnvironment International, 2021, vol. 146, p. 106082
Projectes de recerca europeus
Mostrant elements relacionats per títol, autor i matèria.
Acceptance of near-natural greenspace management relates to ecological and socio-cultural assigned values among European urbanites Lampinen, Jussi; Tuomi, Maria; Fischer, Leonie K.; Neuenkamp, Lena; Alday, Josu G.; Bucharova, Anna; Cancellieri, Laura; Casado-Arzuaga, Izaskun; Čeplová, Natálie; Cerveró, Lluïsa; Deák, Balázs; Eriksson, Ove; Fellowes, Mark D.E.; Fernández de Manuel, Beatriz; Filibeck, Goffredo; González-Guzmán, Adrián; Hinojosa, M. Belen; Kowarik, Ingo; Lumbierres i Bardají, Belén; Miguel, Ana; Pardo, Rosa; Pons i Domènech, Xavier; Rodríguez-García, Encarna; Schröder, Roland; Sperandii, Marta Gaia; Unterweger, Philipp; Valkó, Orsolya; Vázquez, Víctor; Klaus, Valentin H. (Elsevier GmbH on behalf of Gesellschaft für Ökologie, 2020-10-31)Grasslands are widespread elements of urban greenspace providing recreational, psychological and aesthetic benefits to city residents. Two urban grassland types of contrasting management dominate urban greenspaces: frequently ...
Sakhi, Amrit Kaur; Cequier Manciñeiras, Enrique; Becher, Rune; Bølling, Anette Kocbach; Borgen, Anders R.; Schlabach, Martin; Schmidbauer, Norbert; Becher, Georg; Schwarze, Per; Thomsen, Cathrine (Elsevier, 2019-04-09)Both building materials and consumer products have been identified as possible sources for potentially hazardous substances like phthalates, polychlorinated biphenyls (PCBs), organophosphorous flame retardants (OPFRs), ...
Carmona, Andrés; Agüera, Maria L.; Luna-Ruiz, Carlos; Buendía, Paula; Calleros-Basilio, Laura; García-Jerez, Andrea; Rodríguez-Puyol, Manuel; Arias, Manuel; Arias-Guillen, Marta; Arriba, Gabriel de; Ballarin, José; Bernis, Carmen; Fernández i Giráldez, Elvira; García-Rebollo, Sagrario; Mancha, Javier; Peso, Gloria del; Pérez, Estefanía; Poch, Esteban; Portolés, José M.; Rodríguez-Puyol, Diego; Sánchez-Villanueva, Rafael; Sarró, Felipe; Torres, Armando; Martín-Malo, Alejandro; Aljama, Pedro; Ramírez, Rafael; Carracedo, Júlia (American Physiological Society, 2017-04-01)Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease ...