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dc.contributorUniversitat de Lleida
dc.contributor.authorGallart-Palau, Xavier
dc.contributor.authorTarabal Mostazo, Olga
dc.contributor.authorCasanovas i Llorens, Anna
dc.contributor.authorSábado, Javier
dc.contributor.authorCorrea, Francisco
dc.contributor.authorCerveró Cebrià, Clàudia
dc.contributor.authorHereu, Marta
dc.contributor.authorPiedrafita Llorens, Lídia
dc.contributor.authorCalderó i Pardo, Jordi
dc.contributor.authorEsquerda Colell, Josep
dc.descriptionInternational Symposium on Amyotrophic Lateral Sclerosis and Motor Neurone Disease 2013ca_ES
dc.description.abstractPioneering ultrastructural studies have defined different types of synapses (F-, S- and C-type boutons) on lower motoneurons (MNs). C-Type boutons are large nerve terminals characteristic of somatic alpha-MNs and display a subsynaptic cistern adjacent to postsynaptic membrane. The cholinergic nature of C-terminals has been established, and their origin from local interneurons has been deciphered. In a recent study concerning neuregulin-1 (NRG-1) on phrenic MNs, it has been reported that this trophic factor is expressed in cholinergic terminals synapsing these MNs and a presynaptic localization of this protein was suggested. * NRG-1 is concentrated at the subsynaptic cysterns of alpha-MN afferent cholinergic C-terminals. * ALS-resistant MNs at the oculomotor nuclei show low NRG-1 expression. * NRG-1 is developmentally regulated and depends on the maintenance of nerve muscle interactions. * The transient increase in NRG-1-positive spots on MN somata during SMA or ALS progression is in concordance with the described sprouting of C-terminals in ALS.ca_ES
dc.rights(c) Gallart et al., 2014ca_ES
dc.subject.otherNeurones motores--Malaltiesca_ES
dc.titleNeuregulin-1 is associated to postsynaptic sites contacting afferent C-type cholinergic terminals on lower motoneurons: changes in murine models of motoneuron diseasesca_ES

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(c) Gallart et al., 2014
Except where otherwise noted, this item's license is described as (c) Gallart et al., 2014