WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

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2020
Author
Rodriguez-Hernandez, Irene
Maiques Carlos, Oscar
Kohlhammer, Leonie
Cantelli, Gaia
Perdrix-Rosell, Anna
Monger, Joanne
Fanshawe, Bruce
Bridgeman, Victoria L.
Karagiannis, Sophia N.
Penin, Rosa M.
Marcolval, Joaquim
Martí Laborda, Rosa Ma.
Matias-Guiu, Xavier
Fruhwirth, Gilbert O.
Orgaz, Jose L.
Malanchi, Ilaria
Sanz Moreno, Victoria
Suggested citation
Rodriguez-Hernandez, Irene; Maiques Carlos, Oscar; Kohlhammer, Leonie; Cantelli, Gaia; Perdrix-Rosell, Anna; Monger, Joanne; ... Sanz Moreno, Victoria. (2020) . WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. Nature Communications, 2020, vol. 11, núm. 1, p. 5315. https://doi.org/10.1038/s41467-020-18951-2.
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Abstract
Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy.
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http://hdl.handle.net/10459.1/70146
DOI
https://doi.org/10.1038/s41467-020-18951-2
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Nature Communications, 2020, vol. 11, núm. 1, p. 5315
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cc-by (c) Rodriguez-Hernandez, Irene et al., 2020
Except where otherwise noted, this item's license is described as cc-by (c) Rodriguez-Hernandez, Irene et al., 2020