PVT1 long non-coding RNA in gastrointestinal cancer
Martínez Barriocanal, Águeda
MetadataShow full item record
Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. PVT1 (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human cancers and predictive of increased cancer risk in genome-wide association studies (GWAS). Combined, colorectal and gastric adenocarcinomas are the most frequent tumor malignancies and also the leading cause of cancer-related deaths worldwide. PVT1 expression is elevated in gastrointestinal tumors and correlates with poor patient prognosis. In this review, we discuss the mechanisms of action underlying PVT1 oncogenic role in colorectal and gastric cancer such as MYC upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. We also illustrate the potential role of PVT1 as prognostic biomarker and its relationship with resistance to current chemotherapeutic treatments.
Is part ofFrontiers in Oncology, 2020, vol. 10, núm. 38, p.1-16
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Changes in Vitamin C, Phenolic, and Carotenoid Profiles Throughout in Vitro Gastrointestinal Digestion of a Blended Fruit Juice Rodríguez Roque, María Janeth; Rojas Grau, María Alejandra; Elez Martínez, Pedro; Martín Belloso, Olga (American Chemical Society, 2013)The aim of this research was to evaluate the influence of an in vitro gastrointestinal digestion on the stability and bioaccessibility of vitamin C, phenolic compounds, and carotenoids, as well as the antioxidant activity ...
The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and nitric oxide in cultured endothelial cells Martínez-Miguel, Patricia; Valdivielso Revilla, José Manuel; Medrano-Andrés, Diana; Román-García, Pablo; Cano-Peñalver, Jose Luis; Rodríguez-Puyol, Manuel; Rodríguez-Puyol, Diego; López-Ongil, Susana (American Physiological Society, 2014)Despite the presence of vitamin D receptor (VDR) in endothelial cells, the effect of vitamin D on endothelial function is unknown. An unbalanced production of vasoactive endothelial factors such as nitric oxide (NO) or ...
Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice Sandoval, Viviana; Femenias, Antoni; Martínez-Garza, Úrsula; Sanz-Lamora, Hèctor; Castagnini, Juan Manuel; Quifer Rada, Paola; Lamuela Raventós, Rosa Ma.; Marrero González, Pedro F.; Haro, Diego; Relat, Joana (MDPI, 2019-09-01)Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on ...