IL-17A as a potential therapeutic target for patients on peritoneal dialysis
Tejera Muñoz, Antonio
Marquez Exposito, Laura
Rayego Mateos, Sandra
Santos Sanchez, Laura
Fraser, Donald J.
López Cabrera, Manuel
MetadataShow full item record
Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy option for ESRD patients until renal transplantation can be achieved. One important problem in long-term PD patients is peritoneal membrane failure. The mechanisms involved in peritoneal damage include activation of the inflammatory and immune responses, associated with submesothelial immune infiltrates, angiogenesis, loss of the mesothelial layer due to cell death and mesothelial to mesenchymal transition, and collagen accumulation in the submesothelial compact zone. These processes lead to fibrosis and loss of peritoneal membrane function. Peritoneal inflammation and membrane failure are strongly associated with additional problems in PD patients, mainly with a very high risk of cardiovascular disease. Among the inflammatory mediators involved in peritoneal damage, cytokine IL-17A has recently been proposed as a potential therapeutic target for chronic inflammatory diseases, including CKD. Although IL-17A is the hallmark cytokine of Th17 immune cells, many other cells can also produce or secrete IL-17A. In the peritoneum of PD patients, IL-17A-secreting cells comprise Th17 cells, gamma delta T cells, mast cells, and neutrophils. Experimental studies demonstrated that IL-17A blockade ameliorated peritoneal damage caused by exposure to PD fluids. This article provides a comprehensive review of recent advances on the role of IL-17A in peritoneal membrane injury during PD and other PD-associated complications.
Is part ofBiomolecules, 2020, vol. 10, núm. 10, p.1-36
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Lavoz, Carolina; Rayego Mateos, Sandra; Orejudo, Macarena; Opazo Rios, Lucas; Marchant, Vanessa; Marquez Exposito, Laura; Tejera Muñoz, Antonio; Navarro González, Juan F.; Droguett, Alejandra; Ortiz, Alberto; Egido, Jesús; Mezzano, Sergio; Rodrigues-Diez, Raul; Ruiz-Ortega, Marta (MDPI, 2020)Chronic kidney disease has become a major medical issue in recent years due to its high prevalence worldwide, its association with premature mortality, and its social and economic implications. A number of patients gradually ...
Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis Marquez Exposito, Laura; Lavoz, Carolina; Rodrigues-Diez, Raul; Rayego Mateos, Sandra; Orejudo, Macarena; Cantero-Navarro, Elena; Ortiz, Alberto; Egido, Jesús; Selgas, Rafael; Mezzano, Sergio; Ruiz-Ortega, Marta (Frontiers Media, 2018)Chronic kidney disease (CKD) is emerging as an important health problem due to the increase number of CKD patients and the absence of an effective curative treatment. Gremlin has been proposed as a novel therapeutic target ...
Morgado-Pascual, José L.; Marchant, Vanessa; Dolade, Nuria; Rodrigues-Diez, Raul; Suarez-Alvarez, Beatriz; Kerr, Bredford; Valdivielso Revilla, José Manuel; Ruiz-Ortega, Marta; Rayego Mateos, Sandra (Hindawi Publishing Corporation, 2018)The growing incidence of obesity, hypertension, and diabetes, coupled with the aging of the population, is increasing the prevalence of renal diseases in our society. Chronic kidney disease (CKD) is characterized by ...