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dc.contributor.authorValls, Rosa M.
dc.contributor.authorPedret, Anna
dc.contributor.authorCalderón-Pérez, Lorena
dc.contributor.authorLlauradó, Elisabet
dc.contributor.authorPla-Pagà, Laura
dc.contributor.authorCompanys, Judit
dc.contributor.authorMoragas, Ana
dc.contributor.authorMartín Luján, Francisco Manuel
dc.contributor.authorOrtega, Yolanda
dc.contributor.authorGiralt, Montserrat
dc.contributor.authorRomeu, Marta
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorMayneris Perxachs, Jordi
dc.contributor.authorCanela, Núria
dc.contributor.authorPuiggròs i Llavinés, Francesc
dc.contributor.authorCaimari, Antoni
dc.contributor.authorBas, Josep M. del
dc.contributor.authorArola i Ferrer, Lluís
dc.contributor.authorSolà, Rosa
dc.description.abstractPurpose: To assess the sustained and acute effects, as well as the influence of sustained consumption on the acute effects, of orange juice (OJ) with a natural hesperidin content and hesperidin-enriched OJ (EOJ) on blood (BP) and pulse (PP) pressures in pre- and stage-1 hypertensive individuals. Methods: In a randomized, parallel, double-blind, placebo-controlled trial, participants (n = 159) received 500 mL/day of control drink, OJ, or EOJ for 12 weeks. Two dose–response studies were performed at baseline and after 12 weeks. Results: A single EOJ dose (500 mL) reduced systolic BP (SBP) and PP, with greater changes after sustained treatment where a decrease in diastolic BP (DBP) also occurred (P < 0.05). SBP and PP decreased in a dose-dependent manner relative to the hesperidin content of the beverages throughout the 12 weeks (P < 0.05). OJ and EOJ decreased homocysteine levels at 12 weeks versus the control drink (P < 0.05). After 12 weeks of EOJ consumption, four genes related to hypertension (PTX3, NLRP3, NPSR1 and NAMPT) were differentially expressed in peripheral blood mononuclear cells (P < 0.05). Conclusion: Hesperidin in OJ reduces SBP and PP after sustained consumption, and after a single dose, the chronic consumption of EOJ enhances its postprandial effect. Decreases in systemic and transcriptomic biomarkers were concomitant with BP and PP changes. EOJ could be a useful co-adjuvant tool for BP and PP management in pre- and stage-1 hypertensive individuals.ca_ES
dc.description.sponsorshipThe Florida Department of Citrus, an executive agency of the state of Florida, USA, provided a grant and study drinks to the Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Spain. A.P. has a Torres Quevedo contract (Subprograma Estatal de Incorporación, Plan Estatal de Investigación Científica y Técnica y de Innovación).ca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofEuropean Journal of Nutrition, 2021, vol. 60, p. 1277–1288ca_ES
dc.rightscc-by, (c) Valls, Rosa M. et al., 2020ca_ES
dc.subjectOrange juiceca_ES
dc.subjectBlood pressureca_ES
dc.subjectPulse pressureca_ES
dc.titleEffects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study)ca_ES

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cc-by, (c) Valls, Rosa M. et al., 2020
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