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dc.contributor.authorVilanova Fillat, María Belén
dc.contributor.authorFranch-Nadal, Josep
dc.contributor.authorFalguera, Mireia
dc.contributor.authorMarsal Mora, Josep Ramon
dc.contributor.authorCanivell, Sílvia
dc.contributor.authorRubinat, Esther
dc.contributor.authorMiró, Neus
dc.contributor.authorMolló Inesta, Àngels
dc.contributor.authorMata Cases, Manel
dc.contributor.authorGratacòs, Mònica
dc.contributor.authorCastelblanco Echavarría, Esmeralda
dc.contributor.authorMauricio Puente, Dídac
dc.description.abstractThis was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm,p< 0.001; and 37.9% vs. 19.6%;p< 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05-2.57;p= 0.03 and OR = 1.01; 95% CI = 1.00-1.02;p= 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08-2.89;p= 0.023 and OR = 1.20; 95% CI = 1.05-1.38;p= 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear.ca_ES
dc.description.sponsorshipThis research was funded by the Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), the Carlos III National Institute of Health (grant numbers PI15/0625 and PI18/0328) and European Regional Development Fund. CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM) are an initiative of ISCIII, Spain.ca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofJournal of Clinical Medicine, 2020, vol. 9, núm. 7, p. 2-11ca_ES
dc.rightscc-by, (c) Vilanova et al., 2020ca_ES
dc.subjectRisc cardiovascularca_ES
dc.subjectPlaques cariòtidesca_ES
dc.titlePrediabetes is independently associated with subclinical carotid atherosclerosis: an observational study in a non-urban mediterranean populationca_ES

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