Prediabetes is independently associated with subclinical carotid atherosclerosis: an observational study in a non-urban mediterranean population

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2020Author
Vilanova Fillat, María Belén
Franch-Nadal, Josep
Falguera, Mireia
Canivell, Sílvia
Miró, Neus
Molló Inesta, Àngels
Mata Cases, Manel
Gratacòs, Mònica
Castelblanco Echavarría, Esmeralda
Suggested citation
Vilanova Fillat, María Belén;
Franch-Nadal, Josep;
Falguera, Mireia;
Marsal Mora, Josep Ramon;
Canivell, Sílvia;
Rubinat, Esther;
...
Mauricio Puente, Dídac.
(2020)
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Prediabetes is independently associated with subclinical carotid atherosclerosis: an observational study in a non-urban mediterranean population.
Journal of Clinical Medicine, 2020, vol. 9, núm. 7, p. 2-11.
https://doi.org/10.3390/jcm9072139.
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This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm,p< 0.001; and 37.9% vs. 19.6%;p< 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05-2.57;p= 0.03 and OR = 1.01; 95% CI = 1.00-1.02;p= 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08-2.89;p= 0.023 and OR = 1.20; 95% CI = 1.05-1.38;p= 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear.
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Journal of Clinical Medicine, 2020, vol. 9, núm. 7, p. 2-11European research projects
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