Prediabetes is independently associated with subclinical carotid atherosclerosis: an observational study in a non-urban mediterranean population

Vilanova, María-Belén; Franch-Nadal, Josep; Falguera, Mireia; Marsal Mora, Josep Ramon; Canivell, Sílvia; Rubinat, Esther; Miró, Neus; Molló Inesta, Àngels; Mata Cases, Manel; Gratacòs, Mònica; Castelblanco Echavarría, Esmeralda; Mauricio Puente, Dídac

doi:https://doi.org/10.3390/jcm9072139

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Issue date

2020

Author

Vilanova, María-Belén

Franch-Nadal, Josep

Falguera, Mireia

Marsal Mora, Josep Ramon

Canivell, Sílvia

Rubinat, Esther

Miró, Neus

Molló Inesta, Àngels

Mata Cases, Manel

Gratacòs, Mònica

Castelblanco Echavarría, Esmeralda

Mauricio Puente, Dídac

Suggested citation

Vilanova, María-Belén; Franch-Nadal, Josep; Falguera, Mireia; Marsal Mora, Josep Ramon; Canivell, Sílvia; Rubinat, Esther; ... Mauricio Puente, Dídac. (2020) . Prediabetes is independently associated with subclinical carotid atherosclerosis: an observational study in a non-urban mediterranean population. Journal of Clinical Medicine, 2020, vol. 9, núm. 7, p. 2-11. https://doi.org/10.3390/jcm9072139.

Abstract

This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm,p< 0.001; and 37.9% vs. 19.6%;p< 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05-2.57;p= 0.03 and OR = 1.01; 95% CI = 1.00-1.02;p= 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08-2.89;p= 0.023 and OR = 1.20; 95% CI = 1.05-1.38;p= 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear.

URI

http://hdl.handle.net/10459.1/69989

DOI

https://doi.org/10.3390/jcm9072139

Is part of

Journal of Clinical Medicine, 2020, vol. 9, núm. 7, p. 2-11

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Articles publicats (IRBLleida) [883]
Articles publicats (Medicina) [360]

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Except where otherwise noted, this item's license is described as cc-by, (c) Vilanova et al., 2020