Obesity attenuates the efect of sleep apnea on active TGF‑ß1 levels and tumor aggressiveness in patients with melanoma
Martínez‑García, Miguel Ángel
Hernández Blasco, Luis
Montserrat, Josep Maria
García Río, Francisco
MetadataShow full item record
Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases serum levels of active TGF-β1 in patients with cutaneous melanoma (CM), assess their relationship with melanoma aggressiveness and analyze the factors related to TGF-β1 levels in obese and non-obese OSA patients. In a multicenter observational study, 290 patients with CM were underwent sleep studies. TGF-β1 was increased in moderate-severe OSA patients vs. non-OSA or mild OSA patients with CM. In OSA patients, TGF-β1 levels correlated with mitotic index, Breslow index and melanoma growth rate, and were increased in presence of ulceration or higher Clark levels. In CM patients, OSA was associated with higher TGF-β1 levels and greater melanoma aggressiveness only in non-obese subjects. An in vitro model showed that IH-induced increases of TGF-β1 expression in melanoma cells is attenuated in the presence of high leptin levels. In conclusion, TGF-β1 levels are associated with melanoma aggressiveness in CM patients and increased in moderate-severe OSA. Moreover, in non-obese patients with OSA, TGF-β1 levels correlate with OSA severity and leptin levels, whereas only associate with leptin levels in obese OSA patients.
Is part ofScientific Reports, 2020, vol. 10, núm. 15528
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Cubillos‑Zapata, Carolina et al., 2020
Showing items related by title, author, creator and subject.
Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients Almendros, Isaac; Martínez-García, Miguel Angel; Campos-Rodríguez, Francisco; Riveiro-Falkenbach, Erica; Rodríguez-Peralto, José L.; Nagore, Eduardo; Martorell-Calatayud, Antonio; Hernández Blasco, Luis; Bañuls Roca, Jose; Chiner, Eusebi; Sánchez de la Torre, Alicia; Abad-Capa, Jorge; Montserrat, Josep Maria; Pérez-Gil, Amalia; Cabriada, Valentín; Cano-Pumarega, Irene; Corral-Peñafiel, Jaime; Diaz-Cambriles, Trinidad; Mediano, Olga; Dalmau-Arias, Joan; Farré, Ramon; Gozal, David; Spanish Sleep Network (Frontiers Media, 2018)Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced ...
Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial Martínez-García, Miguel Angel; Capote, Francisco; Campos-Rodríguez, Francisco; Lloberes, Patricia; Díaz de Atauri, María Josefa; Somoza, María; Masa, Juan F.; González, Mónica; Sacristán, Lirios; Barbé Illa, Ferran; Durán-Cantolla, Joaquín; Aizpuru, Felipe; Mañas, Eva; Barreiro, Bienvenido; Mosteiro, Mar; Cebrián, Juan J.; Peña, Mónica de la; García-Río, Francisco; Maimó, Andrés; Zapater, Jordi; Hernández, Concepción; Grau Sanmartí, Núria; Montserrat i Capdevila, Josep (American Medical Association, 2013)Importance: More than 70% of patients with resistant hypertension have obstructive sleep apnea (OSA). However, there is little evidence about the effect of continuous positive airway pressure (CPAP) treatment on blood ...
Long-term Effect of CPAP Treatment on Cardiovascular Events in Patients With Resistant Hypertension and Sleep Apnea. Data From the HIPARCO-2 Study Navarro-Soriano, Cristina; Martínez-García, Miguel Angel; Torres, Gerard; Barbé Illa, Ferran; Sánchez de la Torre, Manuel; Caballero-Eraso, Candela; Lloberes, Patricia; Díaz Cambriles, Trinidad; Somoza, María; Masa, Juan F.; González, Mónica; Mañas, Eva; de la Pena, Mónica; García-Río, Francisco; Montserrat, Josep Maria; Muriel, Alfonso; Oscullo, Grace; García-Ortega, Alberto; Posadas, Tomás; Campos-Rodríguez, Francisco; Spanish Sleep Network (Elsevier, 2020)Background: There is some controversy about the effect of continuous positive airway pressure (CPAP) on the incidence of cardiovascular events (CVE). However, the incidence of CVE among patients with both obstructive sleep ...