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dc.contributor.authorGutiérrez Carrasquilla, Liliana
dc.contributor.authorLópez Cano, Carolina
dc.contributor.authorSánchez Peña, Enric
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorDalmases, Mireia
dc.contributor.authorHernández García, Marta
dc.contributor.authorCampos, Angela
dc.contributor.authorGaeta, Anna Michela
dc.contributor.authorCarmona, Paola
dc.contributor.authorHernández, Cristina
dc.contributor.authorSimó, Rafael
dc.contributor.authorLecube Torelló, Albert
dc.description.abstractType 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 diabetes and obstructive sleep apnea (OSA) to explore this. At home, sleep breathing parameters were assessed at baseline and after a 4-month period in which antidiabetic therapy was intensified. Patients who decreased their body mass index ≥2kg/m2 were excluded. Those with an HbA1c reduction ≥0.5% were considered good responders (n = 24). After the follow-up, good responders exhibited an improvement in the apnea–hypopnea index (AHI: 26-1 (95% IC: 8.6–95.0) vs. 20.0 (4.0–62.4) events/hour, p = 0.002) and in time with oxygen saturation below 90% (CT90: 13.3 (0.4–69.0) vs. 8.1 (0.4–71.2) %, p = 0.002). No changes were observed in the group of non–responders (p = 0.722 and p = 0.138, respectively). The percentage of moderate and severe OSA decreased among good responders (p = 0.040). In the wider population, the change in HbA1c correlated positively to decreases in AHI (r = 0.358, p = 0.035) and negatively to increases in the minimum arterial oxygen saturation (r = −0.386, p = 0.039). Stepwise multivariate regression analysis showed that baseline AHI and the absolute change in HbA1c independently predicted decreased AHI (R2 = 0.496). The improvement of glycemic control exerts beneficial effects on sleep breathing parameters in type 2 diabetes, which cannot be attributed merely to weight loss.ca_ES
dc.description.sponsorshipThis study was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria, PI 12/00803, PI 15/00260 and PI18/00964), the European Union, the European Regional Development Fund (Fondo Europeo de Desarrollo Regional, FEDER, “Una manera de hacer Europa”), Fundación Sociedad Española de Endocrinología y Nutrición (SEEN), and Menarini Spain S.A. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and CIBER de Enfermedades Respiratorias (CIBERES) are initiatives of the Instituto Carlos III.ca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofJournal of Clinical Medicine, 2020, vol. 9, núm. 4, p. 1022ca_ES
dc.rightscc-by (c) Gutiérrez Carrasquilla, Liliana et al., 2020ca_ES
dc.subjectGlycated hemoglobinca_ES
dc.titleEffect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Studyca_ES

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cc-by (c) Gutiérrez Carrasquilla, Liliana et al., 2020
Except where otherwise noted, this item's license is described as cc-by (c) Gutiérrez Carrasquilla, Liliana et al., 2020