In recent years, the building sector has been responsible for continuous increase in energy consumption in the world. Space heating and cooling accounts for 34% of this energy consumption in buildings. In this context, using thermal energy storage (TES) can reduce energy consumption for space air conditioning. The use of phase change materials (PCM) as latent heat thermal energy storage (LHTES) system in the building envelope has been of great interest for passive cooling applications due to the high energy storage capacity of this technology. However, in order to utilize the full potential of a PCM, it needs to be fully charged at each cycle. Ventilation during the night is an effective method which can be used in PCMenhanced office buildings with the aim of charging the PCM every required cycle. In the present study, PCM melting temperature of office building in various climate conditions was optimized using a simulation-based optimization and coupled with free cooling operation. Ventilation control strategies were used to improve the cooling energy performance of the PCM enhanced building integrated into envelopes. It was found that charging PCM with night ventilation, especially when using some specific control strategies of natural ventilation operated by external windows opening results in considerable cooling energy savings. The study was conducted for 15 different cities around the world. It was found that, in hot arid conditions, PCM passive cooling system was ineffective. Although, the energy savings were improved by coupling PCM and natural ventilation in these climate conditions. But the benefits were more or less similar to using natural ventilation only. On the other hand, in temperate condition, the effectiveness of PCM was increased from 3.32% to 25.62% by coupling a PCM passive system with night ventilation. It was further improved to 40% when using PCM with temperature-controlled ventilation. Moreover, it can be said that smart control of ventilation can lead to considerable energy savings.