Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study
López Cano, Carolina
Gutiérrez Carrasquilla, Liliana
MetadataShow full item record
In order to compare spirometric maneuvers in adults according to the presence of type 1 diabetes, a case-control study including 75 patients with type 1 diabetes and 75 controls matched by sex, age, and body mass index were designed. In addition, 75 patients with type 1 diabetes were added to examine the potential the impact of subcutaneous insulin therapy on pulmonary function. Lung function measurements were assessed according to the global initiative for chronic obstructive lung disease guidelines. Basal insulin included long-acting insulin analogues and the delivered background insulin in patients with pump therapy. Bolus insulin included rapid-acting insulin analogues and the delivered insulin to cover postprandial hyperglycemias. Patients with type 1 diabetes showed lower spirometric values in comparison to the control group, together with a higher prevalence of forced expiratory volume in the first second (FEV1) <80% (10.7% vs. 2.7%, p = 0.044) and restrictive ventilatory pattern (10.7% vs. 0%, p = 0.006) The dose of basal insulin (U/kg/day) showed a negative correlation with forced vital capacity (FVC) (r = −0.205, p = 0.012) and FEV1 (r = −0.182, p = 0.026). The optimal cut-off value for identifying patients with a restrictive spirometric pattern was 0.5 U/kg/day of basal insulin. Additionally, basal insulin (U/kg/day) independently predicted the presence of both a restrictive spirometric pattern (OR = 77.1 (3.2 to 1816.6), p = 0.007) and an abnormal FEV1 (OR = 29.9 (1.5 to 562.8), p = 0.023). In patients with type 1 diabetes, higher basal insulin dosage seems to be related with an impairment of pulmonary function.
Is part ofJournal of Clinical Medicine, 2020, vol. 9, núm. 5, p. 1249
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes: The Candy Dreams Study Gutiérrez Carrasquilla, Liliana; López Cano, Carolina; Sánchez Peña, Enric; Barbé Illa, Ferran; Dalmases, Mireia; Hernández García, Marta; Campos, Angela; Gaeta, Anna Michela; Carmona, Paola; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2020)Type 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 ...
Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes? López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Barbé Illa, Ferran; Sánchez Peña, Enric; Hernández García, Marta; Martí, Raquel; Ceperuelo-Mallafre, Vicky; Dalmases, Mireia; Fernández-Veledo, Sonia; Vendrell, Joan; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2020)Limited reports exist on the relationships between regulation of oxygen homeostasis and circadian clock genes in type 2 diabetes. We examined whether the expression of Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α ...
López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Sánchez Peña, Enric; González, Jessica; Yeramian Hakim, Andree; Martí, Raquel; Hernández García, Marta; Cao, Gonzalo; Ribelles, Mercè; Gómez Arbonés, Javier; Barril, Silvia; Barbé Illa, Ferran; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (Frontiers Media, 2019)Introduction: Many studies on the impact of type 2 diabetes mellitus (T2DM) on sleep breathing have shown a higher prevalence and severity of sleep apnea-hypopnea syndrome (SAHS) in those with T2DM. Moreover, an increased ...