Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study

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2020
Author
Sánchez Peña, Enric
Mizab, Chadia
Sauret, Ariadna
Barbé Illa, Ferran
Martí, Raquel
López Cano, Carolina
Hernández García, Marta
Gutiérrez Carrasquilla, Liliana
Carmona, Paola
González, Jessica
Dalmases, Mireia
Hernández, Cristina
Simó, Rafael
Lecube Torelló, Albert
Suggested citation
Sánchez Peña, Enric; Mizab, Chadia; Sauret, Ariadna; Barbé Illa, Ferran; Martí, Raquel; López Cano, Carolina; ... Lecube Torelló, Albert. (2020) . Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study. Journal of Clinical Medicine, 2020, vol. 9, núm. 5, p. 1249. https://doi.org/10.3390/jcm9051249.
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Abstract
In order to compare spirometric maneuvers in adults according to the presence of type 1 diabetes, a case-control study including 75 patients with type 1 diabetes and 75 controls matched by sex, age, and body mass index were designed. In addition, 75 patients with type 1 diabetes were added to examine the potential the impact of subcutaneous insulin therapy on pulmonary function. Lung function measurements were assessed according to the global initiative for chronic obstructive lung disease guidelines. Basal insulin included long-acting insulin analogues and the delivered background insulin in patients with pump therapy. Bolus insulin included rapid-acting insulin analogues and the delivered insulin to cover postprandial hyperglycemias. Patients with type 1 diabetes showed lower spirometric values in comparison to the control group, together with a higher prevalence of forced expiratory volume in the first second (FEV1) <80% (10.7% vs. 2.7%, p = 0.044) and restrictive ventilatory pattern (10.7% vs. 0%, p = 0.006) The dose of basal insulin (U/kg/day) showed a negative correlation with forced vital capacity (FVC) (r = −0.205, p = 0.012) and FEV1 (r = −0.182, p = 0.026). The optimal cut-off value for identifying patients with a restrictive spirometric pattern was 0.5 U/kg/day of basal insulin. Additionally, basal insulin (U/kg/day) independently predicted the presence of both a restrictive spirometric pattern (OR = 77.1 (3.2 to 1816.6), p = 0.007) and an abnormal FEV1 (OR = 29.9 (1.5 to 562.8), p = 0.023). In patients with type 1 diabetes, higher basal insulin dosage seems to be related with an impairment of pulmonary function.
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http://hdl.handle.net/10459.1/69573
DOI
https://doi.org/10.3390/jcm9051249
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Journal of Clinical Medicine, 2020, vol. 9, núm. 5, p. 1249
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