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dc.contributor.authorAlza, Lía
dc.contributor.authorVisa Pretel, Anna
dc.contributor.authorHerreros Danés, Judit
dc.contributor.authorCantí Nicolás, Carles
dc.date.accessioned2020-09-08T09:27:00Z
dc.date.available2020-09-08T09:27:00Z
dc.date.issued2020-04-07
dc.identifier.issn0304-419X
dc.identifier.urihttp://hdl.handle.net/10459.1/69470
dc.description.abstractHyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the B-Raf and NRas genes. MAPK inhibitors are effective only shortterm, and recurrence occurs due to functional redundancies or intertwined pathways. The remodeling of Ca2+ signaling is also common in melanoma cells, partly through the increased expression of T-type channels (TTCCs). Here we summarize current knowledge about the prognostic value and molecular targeting of TTCCs. Furthermore, we discuss recent evidence pointing to TTCCs as molecular switches for melanoma chemoresistance, which set the grounds for novel combined therapies against the advanced disease.
dc.description.sponsorshipThis work was funded by the Spanish Ministry of Science, Innovation & Universities (“Retos” Program, grant RTI2018-094739-B-I00 to JH and CC). LA held a predoctoral fellowship from University of Lleida (UdL) and AV from UdL and IRBLleida (Diputació de Lleida).
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.bbcan.2020.188364
dc.relation.ispartofBiochimica et Biophysica Acta-Reviews on Cancer, 2020, vol. 1873, núm. 2, p. 188364
dc.rights(c) Elsevier, 2020
dc.subjectMelanoma
dc.subjectT-type channels
dc.subjectMAPK
dc.subjectRAF/RAS mutants
dc.subjectPTEN mutants
dc.subjectMacroautophagy
dc.subjectChemotherapeutic resistance
dc.titleThe rise of T-type channels in melanoma progression and chemotherapeutic resistance
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2020-09-08T09:27:00Z
dc.identifier.idgrec029978
dc.type.versioninfo:eu-repo/semantics/submittedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1016/j.bbcan.2020.188364


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