The rise of T-type channels in melanoma progression and chemotherapeutic resistance
Fecha de publicación2020-04-07
MetadatosMostrar el registro completo del ítem
Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the B-Raf and NRas genes. MAPK inhibitors are effective only shortterm, and recurrence occurs due to functional redundancies or intertwined pathways. The remodeling of Ca2+ signaling is also common in melanoma cells, partly through the increased expression of T-type channels (TTCCs). Here we summarize current knowledge about the prognostic value and molecular targeting of TTCCs. Furthermore, we discuss recent evidence pointing to TTCCs as molecular switches for melanoma chemoresistance, which set the grounds for novel combined therapies against the advanced disease.
Es parte deBiochimica et Biophysica Acta-Reviews on Cancer, 2020, vol. 1873, núm. 2, p. 188364
Proyectos de investigación europeos
El ítem tiene asociados los siguientes ficheros de licencia: