Toll Like Receptor 2 promoter -196 to -174 deletion affects CD4 levels along HIV infection progression
Bravo, M. J.
Colmenero, J. D.
Real, Luis M.
MetadataShow full item record
TLR2 plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter Insertion/Deletion polymorphism with contradictory data about its role in HIV-1 infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation
with a faster progression to the CD4+<200cells/μL outcome for Deletion allele carriers (Cox regression analysis: Hazard Ratio=2.4; 95%CI:1.4-4, P=0.001). When naïve patients with CD4+<200cells/μL start antiretroviral treatment, rs111200466-Deletion carriers showed a trend towards a slower, recovery rate (time required to reach CD4+>350cells/μL, Cox P=0.36). Our data suggests rs111200466 as a prognosis factor for HIV-1 disease progression.
Is part ofJournal of Infectious Diseases, 2020. In press
European research projects
Showing items related by title, author, creator and subject.
Laplana Lafaja, Marina; Royo Sánchez-Palencia, José Luis; Fibla Palazón, Joan (Elsevier, 2018-08-01)Introduction Vitamin-D plays a role regulating the immune response against to viral infection. In this sense, vitamin-D deficiency may confer increased susceptibility to enveloped virus infection such as HIV, Hepatitis, ...
Herrero, Rocío; Real, Luis M.; Rivero-Juárez, Antonio; Pineda, Juan Antonio; Camacho, Ángela; Macías, Juan; Laplana Lafaja, Marina; Konieczny, Piotr; Márquez, Francisco J.; Souto, Juan Carlos; Soria, José Manuel; Saulle, Irma; Lo Caputo, Sergio; Biasin, Mara; Rivero, Antonio; Fibla Palazón, Joan; Caruz, Antonio (Springer Nature, 2015-03)HIV-1 induces activation of complement through the classical and lectin pathways. However, the virus incorporates several membrane-bound or soluble regulators of complement activation (RCA) that inactivate complement. HIV-1 ...
SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality Laplana Lafaja, Marina; Royo Sánchez-Palencia, José Luis; García Rodríguez, Luis Francisco; Aluja Fabregat, Antón; Gómez-Skarmeta, José Luis; Fibla Palazón, Joan (John Wiley & Sons, 2014-10-26)Impulsive-disinhibited personality (IDP) is a behavioral trait mainly characterized by seeking immediate gratification at the expense of more enduring or long-term gains. This trait has a major role in the development of ...