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dc.contributor.authorNavarro-Soriano, Cristina
dc.contributor.authorMartínez-García, Miguel Angel
dc.contributor.authorTorres, Gerard
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorSánchez de la Torre, Manuel
dc.contributor.authorCaballero-Eraso, Candela
dc.contributor.authorLloberes, Patricia
dc.contributor.authorDíaz Cambriles, Trinidad
dc.contributor.authorSomoza, María
dc.contributor.authorMasa, Juan F.
dc.contributor.authorGonzález, Mónica
dc.contributor.authorMañas, Eva
dc.contributor.authorde la Pena, Mónica
dc.contributor.authorGarcía-Río, Francisco
dc.contributor.authorMontserrat, Josep Maria
dc.contributor.authorMuriel, Alfonso
dc.contributor.authorOscullo, Grace
dc.contributor.authorGarcía-Ortega, Alberto
dc.contributor.authorPosadas, Tomás
dc.contributor.authorCampos-Rodríguez, Francisco
dc.contributor.authorSpanish Sleep Network
dc.description.abstractBackground: There is some controversy about the effect of continuous positive airway pressure (CPAP) on the incidence of cardiovascular events (CVE). However, the incidence of CVE among patients with both obstructive sleep apnea (OSA) ans resistant hypertension (HR) has not been evaluated. Our objective was to analyze the long-term effect of CPAP treatment in patients with RH and OSA on the incidence of CVE. Methods: Multi-center, observational and prospective study of patients with moderate-severe OSA and RH. All the patients were followed up every 3-6 months and the CVE incidence was measured. Patients adherent to CPAP (at least 4h/day) were compared with those with not adherent or those who had not been prescribed CPAP. Results: Valid data were obtained from 163 patients with 64 CVE incidents. Treatment with CPAP was offered to 82%. After 58 months of follow-up, 58.3% of patients were adherent to CPAP. Patients not adherent to CPAP presented a non-significant increase in the total CVE incidence (HR:1.6; 95%CI: 0.96-2.7; p=0.07). A sensitivity analysis showed that patients not adherent to CPAP had a significant increase in the incidence of cerebrovascular events (HR: 3.1; CI95%: 1.07-15.1; p=0.041) and hypertensive crises (HR: 5.1; CI95%: 2.2-11.6; p=0.006), but the trend went in the opposite direction with respect to coronary events (HR: 0.22; CI95%: 0.05-1.02; p=0.053). Conclusions: In patients with RH and moderate-severe OSA, an uneffective treatment with CPAP showed a trend toward an increase in the incidence of CVE (particularly neurovascular events and hypertensive crises) without any changes with respect to coronary events.ca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofArchivos de Bronconeumología, 2020, vol. 57, núm. 3, p. 165-171ca_ES
dc.rightscc-by-nc-nd, (c) Navarro-Soriano et al., 2020ca_ES
dc.subjectAccidente cerebrovascularca_ES
dc.subjectApnea del sueñoca_ES
dc.subjectCardiovascular eventsca_ES
dc.subjectCerebrovascular diseaseca_ES
dc.subjectCoronary heart diseaseca_ES
dc.subjectEnfermedad cerebrovascularca_ES
dc.subjectEnfermedad coronariaca_ES
dc.subjectEventos cardiovascularesca_ES
dc.subjectHipertensión resistenteca_ES
dc.subjectPresión positiva continua en las vías respiratoriasca_ES
dc.subjectResistant hypertensionca_ES
dc.subjectSleep apneaca_ES
dc.titleLong-term Effect of CPAP Treatment on Cardiovascular Events in Patients With Resistant Hypertension and Sleep Apnea. Data From the HIPARCO-2 Studyca_ES
dc.title.alternativeEfecto a largo plazo del tratamiento de la presión positiva continua en las vías respiratorias en eventos cardiovasculares en pacientes con hipertensión resistente y apnea del sueño. Datos del estudio HIPARCO-2ca_ES

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cc-by-nc-nd, (c) Navarro-Soriano et al., 2020
Except where otherwise noted, this item's license is described as cc-by-nc-nd, (c) Navarro-Soriano et al., 2020