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dc.contributor.authorBarceló Gómez, Carla
dc.contributor.authorSisó, Pol
dc.contributor.authorMaiques Carlos, Oscar
dc.contributor.authorde la Rosa, Inés
dc.contributor.authorMartí Laborda, Rosa Ma.
dc.contributor.authorMacià Armengol, Anna
dc.date.accessioned2020-06-23T09:38:49Z
dc.date.available2020-06-23T09:38:49Z
dc.date.issued2020
dc.identifier.issn2072-6694
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/10459.1/69114
dc.description.abstractT-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential in the melanoma field. We describe a novel correlation between the Cav3.1 isoform and the increased basal autophagy in BRAFV600E-mutant melanomas and after acquired resistance to BRAF inhibitors. Indeed, TTCC blockers reduce melanoma cell viability and migration/invasion in vitro and tumor growth in mice xenografts in both BRAF-inhibitor-sensitive and -resistant scenarios. These studies open a new, promising therapeutic approach for disseminated melanoma and improved treatment in BRAFi relapsed melanomas, but further validation and clinical trials are needed for it to become a real therapeutic optionca_ES
dc.description.sponsorshipThis work was supported by grants from ISCIII/FEDER “Una manera de hacer Europa” (PI1500711 to RMM; PI18/00573 to RMM and AM). CB and PS hold a pre-doctoral fellowship from UdL-IRBLleida. RI holds a pre-doctoral fellowship from Asociación Española Contra el Cancer (AECC), Catalunya Contra el Cancer, Lleida. AM holds a post-doctoral fellowship from Asociación Española Contra el Cancer (AECC).ca_ES
dc.language.isoengca_ES
dc.publisherMDPIca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.3390/cancers12020391ca_ES
dc.relation.ispartofCancers, 2020, vol. 12, núm. 2, p.391-ca_ES
dc.rightscc-by, (c) Barceló et al., 2020ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectT-type calcium channels (TTCCs)ca_ES
dc.subjectMelanomaca_ES
dc.subjectBRAFV600Eca_ES
dc.subjectTherapyca_ES
dc.subjectResistanceca_ES
dc.titleT-Type Calcium Channels: A Potential Novel Target in Melanomaca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec030696
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.3390/cancers12020391


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cc-by, (c) Barceló et al., 2020
Except where otherwise noted, this item's license is described as cc-by, (c) Barceló et al., 2020