Resilience effects of SGK1 and TAP1 DNA markers during PRRSV outbreaks in reproductive sows

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Laplana Lafaja, MarinaLaplana Lafaja, Marina - ORCID ID
Estany Illa, JoanEstany Illa, Joan - ORCID ID
Fraile Sauce, Lorenzo JoséFraile Sauce, Lorenzo José - ORCID ID
Pena i Subirà, Ramona NatachaPena i Subirà, Ramona Natacha - ORCID ID
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cc-by (c) Laplana Lafaja et al., 2020
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The porcine reproductive and respiratory syndrome virus (PRRSV) is a major infectious stressor that causes serious health problems and productivity drops. Based on previous genome-wide analyses, we selected SGK1 and TAP1 as candidate genes for resilience, and genotyped three mutations, including a 3′UTR variant SGK1_rs338508371 and two synonymous variants TAP1_rs1109026889 and TAP1_rs80928141 in 305 Landrace × Large White sows. All polymorphisms affected the reproductive performance in the outbreak, but not during the endemic phase, thereby indicating a potential use of these markers for resilience. Moreover, some genotypes were associated with a stable performance across PRRSV phases. Thus, in the outbreak, the SGK1_rs338508371 AA sows had less piglets born alive (p < 0.0001) and more stillborns (p < 0.05) while other sows were able to keep their productivity. During the outbreak, TAP1_rs80928141 GG sows had less piglets born alive (p < 0.05) and both TAP1 polymorphisms influenced the number of mummies in an additive manner (p < 0.05). Remarkably, TAP1_rs80928141 AA sows had around one mummy more than GG sows (p < 0.01). Resilience to PRRSV could be improved by including the SGK1 and TAP1 markers in crossbreeding and/or selection schemes, as they contribute to maintaining a stable number of piglets born alive and lost, particularly mummies, despite the outbreak.
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Animals, 2020, vol. 10, num. 5, p. 902