Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study
Gosalbes, Maria José
Valls, Rosa M.
Ludwig, Iziar A.
MetadataShow full item record
Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive gut microbiota analysis and targeted metabolomics in a cross-sectional study
of 29 non-treated hypertensive (HT) and 32 normotensive (NT) subjects. We determined fecal microbiota composition by 16S rRNA gene sequencing and bacterial functions by metagenomic analysis. The microbial metabolites analysed were short chain fatty acids (SCFA) both in plasma and feces, and trimethylamine N-oxide (TMAO) in plasma. The overall bacterial composition and diversity of bacterial community in the two groups were not significantly different. However, Ruminococcaceae NK4A214, Ruminococcaceae_UCG-010, Christensenellaceae_R-7, Faecalibacterium prausnitzii and Roseburia hominis were found to be significantly enriched in NT group, whereas, Bacteroides coprocola, Bacteroides plebeius and genera of Lachnospiraceae were increased in HT patients. We found a positive correlation between the HT-associated species and systolic and diastolic blood pressure after adjusted for measured confounders. SCFA showed antagonistic results in plasma and feces, detecting in HT subjects significant higher levels in feces and lower levels in plasma, which could indicate a less efficient SCFA absorption. Overall, our results present a disease classifier based on microbiota and bacterial metabolites to discriminate HT individuals from NT controls in a first disease grade prior to drug treatment.
Is part ofScientific Reports, 2020, vol. 10, p. 6436
Except where otherwise noted, this item's license is described as cc-by (c) Calderón-Pérez, Lorena et al., 2020
Showing items related by title, author, creator and subject.
Granado-Serrano, Ana Belén; Martín Garí, Meritxell; Sánchez, V.; Riart Solans, M.; Berdún Hernández, Rebeca; Ludwig, Iziar A.; Rubió Piqué, Laura; Vilaprinyo Terré, Ester; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (Nature Research, 2019)Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of ...
In vivo biotransformation of (poly)phenols and anthocyanins of red-fleshed apple and identification of intake biomarkers Yuste, Silvia; Ludwig, Iziar A.; Rubió Piqué, Laura; Romero Fabregat, Mª Paz; Pedret, Anna; Valls, Rosa M.; Solà, Rosa; Motilva Casado, Mª José; Macià i Puig, Ma Alba (Elsevier, 2019)The aim of this study was to investigate comprehensively the metabolic pathways and human bioavailability of anthocyanins and other phenolic compounds in apple matrix, and to elucidate potential intake biomarkers. After ...
The effects and associations of whole-apple intake on diverse cardiovascular risk factors. A narrative review Sandoval-Ramírez, Berner Andrée; Catalan, Ursula; Calderón-Pérez, Lorena; Companys, Judit; Pla-Pagà, Laura; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Solà, Rosa (Taylor & Francis Group, 2020-01-13)Apples are among the world’s most consumed fruits. However, while the impact of whole-apple intake on cardiovascular disease (CVD) remains unknown. This narrative review summarizes a novel integrated view of whole-apple ...