The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sample

Soler, Jordi; Arias Sampériz, Bárbara; Moya Higueras, Jorge; Ibáñez Ribes, Manuel Ignacio; Ortet i Fabregat, Generós; Fañanás Saura, Lourdes; Fatjó-Vilas, Mar

doi:https://doi.org/10.1016/j.pnpbp.2018.08.009

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Issue date

2019

Author

Soler, Jordi

Arias Sampériz, Bárbara

Moya Higueras, Jorge

Ibáñez Ribes, Manuel Ignacio

Ortet i Fabregat, Generós

Fañanás Saura, Lourdes

Fatjó-Vilas, Mar

Suggested citation

Soler, Jordi; Arias Sampériz, Bárbara; Moya Higueras, Jorge; Ibáñez Ribes, Manuel Ignacio; Ortet i Fabregat, Generós; Fañanás Saura, Lourdes; Fatjó-Vilas, Mar; . (2019) . The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sample. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, vol. 89, p. 174-180. https://doi.org/10.1016/j.pnpbp.2018.08.009.

Abstract

The ZNF804A gene and cannabis use are risk factors for psychosis and both have also been associated with schizotypal traits. This study aimed to investigate: i) the association of lifetime cannabis use (and its dose effect) with schizotypal personality traits, and ii) whether the genetic variability

at ZNF804A gene modulates that association. Our sample consisted of 385 Spanish non-clinical subjects (43.1% males, mean age = 21.11(2.19)). Schizotypy was evaluated using the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (SPQ-CP), Interpersonal (SPQ-I) and Disorganized (SPQ-D). Subjects were classified according to their frequency of cannabis consumption, and dichotomized as users or non-users. The effects of a genetic variant of ZNF804A (rs1344706) and cannabis use, as well as their interaction, on each of the three SPQ-B factors were assessed using linear models and permutation tests. Sex, SCL anxiety scores and use of other drugs were included as covariates. Our analysis showed a significant relationship between ZNF804A and SPQ-I: AA genotype was associated with higher scores (β = 0.885 pFDR = .018). An interaction between the AA genotype and lifetime cannabis use was found in SPQ-CP (β = 1.297 pFDR = 0.018). This interaction showed a dose–effect pattern among AA subjects: schizotypy scores increased with increasing frequency of cannabis use (sporadic users: β = 0.746 pFDR = 0.208; monthly users: β = 1.688 pFDR = 0.091; intense users: β = 1.623 pFDR = 0.038). These results add evidence on that the ZNF804A gene is associated with schizotypy and suggest that the interaction between cannabis use and ZNF804A genotype coul

URI

http://hdl.handle.net/10459.1/68402

DOI

https://doi.org/10.1016/j.pnpbp.2018.08.009

Is part of

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, vol. 89, p. 174-180