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dc.contributor.authorCarnes Vendrell, Anna
dc.contributor.authorDeus Yela, Juan
dc.contributor.authorMolina Seguin, Jessica
dc.contributor.authorPifarré Paredero, Josep
dc.contributor.authorPurroy Garcia, Francisco
dc.date.accessioned2020-03-24T11:24:37Z
dc.date.available2020-03-24T11:24:37Z
dc.date.issued2019
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10459.1/68322
dc.description.abstractFew previous studies have focused on affective impairment after transient ischemic attack (TIA) and/or minor stroke. The aim was to establish the prevalence, evolution and predictors of post-stroke depression (PSD) and post-stroke apathy (PSA) over a 12-month follow-up period. We prospectively included TIA and minor stroke patients (NIHSS ≤4) who had undergone magnetic resonance imaging <7 days. PSD was diagnosed according to DSM-5 criteria and PSA was defined based on an Apathy Evaluation Scale (AES-C) score of ≥37. Clinical and neuroimaging variables (presence and patterns of lesion, cerebral bleeds and white matter disease) were analysed in order to find potential predictors for PSD and PSA. Follow-up was performed at 10 days and after 2, 6, 9 and 12 months. 82 patients were included (mean 66.4 [standard deviation11.0] years) of whom 70 completed the follow-up. At 10 days, 36 (43.9%) and 28 (34.1%) patients respectively were diagnosed with PSD and PSA. At 12 months, 25 of 70 (35.7%) patients still had PSA, but only 6 of 70 (8.6%) had PSD. Beck Depression Inventory-II score, mini mental state examination (MMSE) and a previous history of depression or anxiety were predictors for PSD. While MMSE score, The Montgomery Asberg Depression Rating Scale and having previously suffered a stroke were also risk factors for PSA. Acute basal ganglia lesion and periventricular leukoaraiosis were associated with PSA while deep leukorariosis with PSD. Despite the presence of few or only transient symptoms, PSD and PSA frequent appear early after TIA and minor stroke. Unlike PSD, apathy tends to persist during follow-up.ca_ES
dc.description.sponsorshipThe Management Agency Responsible for University and Research Funding of the Catalan Administration participated in the organisation of the Research Group SGR 2017/1198 and SGR 2017/1628.ca_ES
dc.language.isoengca_ES
dc.publisherNature Researchca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1038/s41598-019-52721-5ca_ES
dc.relation.ispartofScientific Reports, 2019, vol. 9, núm. 16248ca_ES
dc.rightscc-by, (c) Carnes-Vendrell et al., 2019ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherDepressió psíquicaca_ES
dc.subject.otherAnsietatca_ES
dc.subject.otherAtac isquèmic transitorica_ES
dc.titleDepression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictorsca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1038/s41598-019-52721-5


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cc-by, (c) Carnes-Vendrell et al., 2019
Except where otherwise noted, this item's license is described as cc-by, (c) Carnes-Vendrell et al., 2019