Cellular innate immunity against PRRSV and swine influenza viruses
MetadataShow full item record
Porcine respiratory disease complex (PRDC) is a polymicrobial syndrome that results from a combination of infectious agents, such as environmental stressors, population size, management strategies, age, and genetics. PRDC results in reduced performance as well as increased mortality rates and production costs in the pig industry worldwide. This review focuses on the interactions of two enveloped RNA viruses—porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SwIV)—as major etiological agents that contribute to PRDC within the porcine cellular innate immunity during infection. The innate immune system of the porcine lung includes alveolar and parenchymal/interstitial macrophages, neutrophils (PMN), conventional dendritic cells (DC) and plasmacytoid DC, natural killer cells, and γδ T cells, thus the in vitro and in vivo interactions between those cells and PRRSV and SwIV are reviewed. Likewise, the few studies regarding PRRSV-SwIV co-infection are illustrated together with the different modulation mechanisms that are induced by the two viruses. Alterations in responses by natural killer (NK), PMN, or γδ T cells have not received much attention within the scientific community as their counterpart antigen-presenting cells and there are numerous gaps in the knowledge regarding the role of those cells in both infections. This review will help in paving the way for future directions in PRRSV and SwIV research and enhancing the understanding of the innate mechanisms that are involved during infection with these viruses.
Is part ofVeterinary Sciences, 2019, vol. 6, núm. 1, article number 26, p. 1-26
European research projects
Except where otherwise noted, this item's license is described as cc-by (c) Crisci, Elisa et al., 2019
Showing items related by title, author, creator and subject.
Identification of a newly conserved SLA-II epitope in a structural protein of swine influenza virus Baratelli, Massimiliano; Morgan, Sophie; Hemmink, Johanneke Dinie; Reid, Elisabeth; Carr, Brigid Veronica; Lefevre, Eric; Montaner Tarbes, Sergio Roberto; Charleston, Bryan; Fraile Sauce, Lorenzo José; Tchilian, Elma; Montoya, Maria (Frontiers Media, 2020)Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV ...
Genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006-2007 Baratelli, Massimiliano; Cordoba, Lorena; Perez, Lester Josue; Maldonado, Jaime; Fraile Sauce, Lorenzo José; Núñez, José I.; Montoya, Maria (Elsevier, 2014)Swine influenza virus is one of the most important pathogens involved in the swine respiratory disease complex. Recent serological surveys showed a high prevalence of swine influenza strains belonging to the H1N1, H1N2 and ...
Crisci, Elisa; Fraile Sauce, Lorenzo José; Valentino, Sonia; Martínez Guinó, Laura; Bottazzi, Barbara; Mantovani, Alberto; Montoya, Maria (Elsevier, 2014)Long pentraxin 3 (PTX3) is a conserved pattern-recognition secreted protein and a host-defence-related component of the humoral innate immune system. The aim of the present study was to characterize swine PTX3 (SwPTX3) ...