Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain
Gallego Fabrega, Cristina
de Torres-Chacón, Reyes
Cabezas, Juan A.
Martí Fàbregas, Joan
Prats Sánchez, Luis
Camps Renom, Pol
Freijo, María del Mar
MetadataShow full item record
Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 previously associated with acenocoumarol maintenance dose in a Genome-Wide Association study (GWAs) in Dutch population are associated with stroke recurrence, intracranial haemorrhage (ICH) and acenocoumarol maintenance dose in a Spanish population. We performed a GWAs using Human Core Exome-chip (Illumina) in 78 patients stroke patients treated with acenocoumarol for secondary prevention enrolled as part of the prospective investigator-initiated study (IIS) SEDMAN Study. Patients were followed-up a median of 12.8 months. Three and eight patients had recurrent stroke and ICH events, respectively. We found 14 of the 49 published variants associated with acenocoumarol maintenance dose (p < 0.05). Six polymorphisms were associated with stroke recurrence and four variants with ICH (p < 0.05). In conclusion, variants in VKORC1 and CYP2C9 are associated with acenocoumarol maintenance dose, stroke recurrence and ICH in a Spanish cohort. These results highlight the relevance of studying pharmacogenetics associated with efficacy and safety of anticoagulant drugs and justify studies with larger sample size and different ethnic populations.
Is part ofScientific Reports, 2020, vol. 10, núm. 2806
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Martí Fàbregas, Joan; Medrano-Martorell, Santiago; Merino, Elisa; Prats Sánchez, Luis; Marín, Rebeca; Delgado Mederos, Raquel; Camps Renom, Pol; Martínez Domeño, Alejandro; Gómez Choco, Manuel; Lara, Lidia; Casado-Naranjo, Ignacio; Cánovas, David; Torres, Maria José; Freijo, María del Mar; Calleja, Ana; Bravo, Yolanda; Cocho, Dolores; Rodríguez-Campello, Ana; Zandio, Beatriz; Fuentes, Blanca; Felipe, Alicia de; Llull, Laura; Maestre, José; Hernández, María; Garcés, Moisés; Arce-Borda, Ana Maria de; Palomeras, Ernest; Rodríguez-Yáñez, Manuel; Díaz-Maroto, Inma; Serrano, Marta; Fernández-Domínguez, Jéssica; Sanahuja Montesinos, Jordi; Purroy Garcia, Francisco; Zedde, Marialuisa; Delgado-Mengual, Jordi; Gich, Ignasi (Nature Publishing Group, 2018)We investigated whether pre-treatment with statins is associated with surrogate markers of amyloid and hypertensive angiopathies in patients who need to start long-term oral anticoagulation therapy. A prospective multicenter ...
Jové Font, Mariona; Mauri-Capdevila, Gerard; Suárez-Luis, Idalmis; Cambray Carner, Serafí; Sanahuja Montesinos, Jordi; Quilez Martínez, Alejandro; Farré, Joan; Benabdelhak Abbou, Ikram; Pamplona Gras, Reinald; Portero Otín, Manuel; Purroy Garcia, Francisco (American Academy of Neurology, 2015)Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ...
Vena Martínez, Ana Belén; Cambray Carner, Serafí; Quilez Martínez, Alejandro; Molina Seguin, Jessica; Colàs Campàs, Laura; Sanahuja Montesinos, Jordi; González Mingot, Cristina; Purroy Garcia, Francisco; Benabdelhak Abbou, Ikram; Mauri-Capdevila, Gerard; Gil-Villar, María Pilar (Wiley, 2016)