Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study

Carbonell, Marc; Alonso, Núria; Castelblanco Echavarría, Esmeralda; Real, Jordi; Ramírez-Morros, Anna; Simó, Rafael; Hernández, Cristina; Jurjo Campo, Carmen; Traveset Maeso, Alicia; Valldeperas, Xavier; Mauricio Puente, Dídac

doi:https://doi.org/10.3390/jcm8091412

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Issue date

2019

Author

Carbonell, Marc

Alonso, Núria

Castelblanco Echavarría, Esmeralda

Real, Jordi

Ramírez-Morros, Anna

Simó, Rafael

Hernández, Cristina

Jurjo Campo, Carmen

Traveset Maeso, Alicia

Valldeperas, Xavier

Mauricio Puente, Dídac

Suggested citation

Carbonell, Marc; Alonso, Núria; Castelblanco Echavarría, Esmeralda; Real, Jordi; Ramírez-Morros, Anna; Simó, Rafael; ... Mauricio Puente, Dídac. (2019) . Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study. Journal of Clinical Medicine, 2019, vol. 8, núm. 9. https://doi.org/10.3390/jcm8091412.

Abstract

Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To assess the inner retinal and choroidal structural changes in type 1 diabetic subjects (T1D), a cross-sectional study was conducted in 242 T1D patients and in 69 age-matched, non-diabetic individuals. The nasal retinal nerve fibre layer (RNFL) thickness was lower in T1D patients without DR (p < 0.001), with mild DR (p < 0.001), and with advanced DR (p < 0.001) compared to control subjects. The ganglion cell layer (GCL) thickness was lower in T1D patients with advanced DR compared to those with mild DR (p = 0.003) and without DR (p < 0.001) and compared to the control subjects (p < 0.001). T1D subjects with no DR and mild DR had higher CT than the control subjects, but the CT in T1D patients with advanced DR was lower (p = 0.038) than that in T1D subjects with mild DR and was not significantly different from that of the control subjects. In conclusion, T1D subjects showed a significant thinning of the nasal RNFL in the early stages of the disease, even before any vascular changes in the retina. A decrease in the GCL thickness during advanced DR stages was observed. Choroidal thickness was higher in T1D subjects without DR and in early DR stages but decreased in advanced stages.

URI

http://hdl.handle.net/10459.1/68231

DOI

https://doi.org/10.3390/jcm8091412

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Journal of Clinical Medicine, 2019, vol. 8, núm. 9

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Except where otherwise noted, this item's license is described as cc-by, (c) Carbonell et al., 2019