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dc.contributor.authorSantamaria-Martos, Fernando
dc.contributor.authorBenítez, Iván
dc.contributor.authorOrtega Delgado, Francisco José
dc.contributor.authorZapater, Andrea
dc.contributor.authorGiron, Cristina
dc.contributor.authorPinilla, Lucía
dc.contributor.authorPacual, Lydia
dc.contributor.authorCortijo, Anunciación
dc.contributor.authorDalmases, Mireia
dc.contributor.authorFernandez-Real, Jose Manuel
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorSánchez de la Torre, Manuel
dc.description.abstractEvaluation of microRNAs (miRNAs) could allow characterization of the obstructive sleep apnea (OSA) and help diagnose it more accurately. We aimed to examine circulating miRNA profiles to establish the differences between non-OSA and OSA patients. Additionally, we aimed to analyse the effect of continuous positive airway pressure (CPAP) treatment on the miRNA profile. This observational, longitudinal study included 230 subjects referred to the Sleep Unit due to suspected OSA. Expression profiling of 188 miRNAs in plasma was performed in 27 subjects by TaqMan-Low-Density-Array. OSA-related miRNAs were selected for validation by RT-qPCR in 203 patients. Prediction models were built to discriminate between non-OSA and OSA: 1) NoSAS-score, 2) differentially expressed miRNAs, and 3) combination of NoSAS-score plus miRNAs. The differentially expressed miRNAs were measured after 6 months of follow-up. From the 14 miRNAs selected for validation, 6 were confirmed to be differentially expressed. The areas under the curve were 0.73 for the NoSAS-score, 0.81 for the miRNAs and 0.86 for the combination. After 6 months of CPAP treatment, miRNA levels in the OSA group seem to approximate to non-OSA levels. A cluster of miRNAs was identified to differentiate between non-OSA and OSA patients. CPAP treatment was associated with changes in the circulating miRNA profile.ca_ES
dc.description.sponsorshipThe founding sources have no role in the writing, data collection, analysis or interpretation of the study. The project is supported by PI 14/01266 and PI 18/00449 from the Instituto de Salud Carlos III (ISCIII), Fondo Europeo de Desarrollo Regional (FEDER), Sociedad Española de Neumología y Cirugía Torácica (SEPAR) and Societat Catalana de Pneumologia (SOCAP). The work is supported by IRBLleida Biobank (B.0000682) and PLATAFORMA BIOBANCOS PT17/0015/0027”. F.S.-M. is the recipient of a predoctoral fellowship from “AGAUR-University of Lleida” and Convocatòria d’Ajuts 2018 de Promoció a la Recerca en Salutca_ES
dc.publisherNature Publishing Groupca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofScientific Reports, 2019, vol. 9, núm. 13456ca_ES
dc.rightscc-by, (c) Santamaria-Martos et al., 2019ca_ES
dc.subject.otherMarcadors bioquímicsca_ES
dc.subject.otherSíndromes d'apnea del sonca_ES
dc.titleCirculating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosisca_ES

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cc-by, (c) Santamaria-Martos et al., 2019
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