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Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study

dc.contributor.authorCiudin, Andreea
dc.contributor.authorFidilio, Enzamaria
dc.contributor.authorOrtiz, Angel
dc.contributor.authorPich, Sara
dc.contributor.authorSalas, Eduardo
dc.contributor.authorMesa, Jordi
dc.contributor.authorHernández, Cristina
dc.contributor.authorSimó-Servat, Olga
dc.contributor.authorLecube Torelló, Albert
dc.date.accessioned2020-03-09T08:44:02Z
dc.date.available2020-03-09T08:44:02Z
dc.date.issued2019
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10459.1/68162
dc.description.abstractIntroduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of either weight loss or diabetes remission. Research design and methods: A case-control study in which 96 females (47 with type 2 diabetes) underwent Roux-en-Y gastric by-pass were included. The DNA was extracted from saliva samples and SNPs were examined and grouped into 3 GPS. ROC curves were used to calculate sensitivity and specificity. Results: A highly sensitive and specific predictive model of response to BS was obtained by combining the GPS in non-diabetic subjects. This combination was different in diabetic subjects and highly predictive of diabetes remission. Additionally, the model was able to predict the weight regain and type 2 diabetes relapse after 5 years' follow-up. Conclusions: Genetic testing is a simple, reliable and useful tool for implementing personalized medicine in type 2 diabetic patients requiring BS.ca_ES
dc.description.sponsorshipThis study was supported by grants from the “Pla Estratègic de Recerca i Innovació en Salut” (PERIS) 2016-2020 (SLT002/16/00497), the Instituto de Salud Carlos III (Fondo de Investigación sanitaria, PI 18/00964), and the European Union (European Regional Development Fund). O.S. is a recipient of a “Río Hortega” fellowship grant from the Instituto de Salud Carlos III.ca_ES
dc.language.isoengca_ES
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1186/s12933-019-0897-yca_ES
dc.relation.ispartofJournal of Clinical Medicine, 2019, vol. 8, núm. 7, p. 964ca_ES
dc.rightscc-by (c) Ciudin et al., 2019ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDiabetesca_ES
dc.subjectObesityca_ES
dc.subjectBariatric surgeryca_ES
dc.titleGenetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Studyca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1186/s12933-019-0897-y


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