dc.contributor.author | Ciudin, Andreea | |
dc.contributor.author | Fidilio, Enzamaria | |
dc.contributor.author | Ortiz, Angel | |
dc.contributor.author | Pich, Sara | |
dc.contributor.author | Salas, Eduardo | |
dc.contributor.author | Mesa, Jordi | |
dc.contributor.author | Hernández, Cristina | |
dc.contributor.author | Simó-Servat, Olga | |
dc.contributor.author | Lecube Torelló, Albert | |
dc.date.accessioned | 2020-03-09T08:44:02Z | |
dc.date.available | 2020-03-09T08:44:02Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | http://hdl.handle.net/10459.1/68162 | |
dc.description.abstract | Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of either weight loss or diabetes remission.
Research design and methods: A case-control study in which 96 females (47 with type 2 diabetes) underwent Roux-en-Y gastric by-pass were included. The DNA was extracted from saliva samples and SNPs were examined and grouped into 3 GPS. ROC curves were used to calculate sensitivity and specificity.
Results: A highly sensitive and specific predictive model of response to BS was obtained by combining the GPS in non-diabetic subjects. This combination was different in diabetic subjects and highly predictive of diabetes remission. Additionally, the model was able to predict the weight regain and type 2 diabetes relapse after 5 years' follow-up.
Conclusions: Genetic testing is a simple, reliable and useful tool for implementing personalized medicine in type 2 diabetic patients requiring BS. | ca_ES |
dc.description.sponsorship | This study was supported by grants from the “Pla Estratègic de Recerca i Innovació en Salut” (PERIS) 2016-2020 (SLT002/16/00497), the Instituto de Salud Carlos III (Fondo de Investigación sanitaria, PI 18/00964), and the European Union (European Regional Development Fund). O.S. is a recipient of a “Río Hortega” fellowship grant from the Instituto de Salud Carlos III. | ca_ES |
dc.language.iso | eng | ca_ES |
dc.publisher | MDPI | |
dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.1186/s12933-019-0897-y | ca_ES |
dc.relation.ispartof | Journal of Clinical Medicine, 2019, vol. 8, núm. 7, p. 964 | ca_ES |
dc.rights | cc-by (c) Ciudin et al., 2019 | ca_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Diabetes | ca_ES |
dc.subject | Obesity | ca_ES |
dc.subject | Bariatric surgery | ca_ES |
dc.title | Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study | ca_ES |
dc.type | info:eu-repo/semantics/article | ca_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
dc.identifier.doi | https://doi.org/10.1186/s12933-019-0897-y | |