Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study

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2019
Author
Ciudin, Andreea
Fidilio, Enzamaria
Ortiz, Angel
Pich, Sara
Salas, Eduardo
Mesa, Jordi
Hernández, Cristina
Simó-Servat, Olga
Lecube Torelló, Albert
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Ciudin, Andreea; Fidilio, Enzamaria; Ortiz, Angel; Pich, Sara; Salas, Eduardo; Mesa, Jordi; ... Lecube Torelló, Albert. (2019) . Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study. Journal of Clinical Medicine, 2019, vol. 8, núm. 7, p. 964. https://doi.org/10.1186/s12933-019-0897-y.
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Abstract
Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of either weight loss or diabetes remission. Research design and methods: A case-control study in which 96 females (47 with type 2 diabetes) underwent Roux-en-Y gastric by-pass were included. The DNA was extracted from saliva samples and SNPs were examined and grouped into 3 GPS. ROC curves were used to calculate sensitivity and specificity. Results: A highly sensitive and specific predictive model of response to BS was obtained by combining the GPS in non-diabetic subjects. This combination was different in diabetic subjects and highly predictive of diabetes remission. Additionally, the model was able to predict the weight regain and type 2 diabetes relapse after 5 years' follow-up. Conclusions: Genetic testing is a simple, reliable and useful tool for implementing personalized medicine in type 2 diabetic patients requiring BS.
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http://hdl.handle.net/10459.1/68162
DOI
https://doi.org/10.1186/s12933-019-0897-y
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Journal of Clinical Medicine, 2019, vol. 8, núm. 7, p. 964
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Except where otherwise noted, this item's license is described as cc-by (c) Ciudin et al., 2019