The effects and associations of whole-apple intake on diverse cardiovascular risk factors. A narrative review
Sandoval-Ramírez, Berner Andrée
Catalán Santos, Úrsula
Ludwig, Iziar A.
MetadataShow full item record
Apples are among the world’s most consumed fruits. However, while the impact of whole-apple intake on cardiovascular disease (CVD) remains unknown. This narrative review summarizes a novel integrated view of whole-apple intake, CVD risk association (through observational studies; OSs), and the effects on CVD risk factors (randomized trials; RTs). In 8 OSs, whole-apple intake was associated with a reduced risk of CVD mortality, ischemic heart disease mortality, stroke mortality, all-cause mortality, and severe abdominal aortic calcification, as well as with lower C-reactive protein (CRP) concentrations. In 8 RTs, whole-apple consumption reduced total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, pulse pressure, and plasma inflammatory cytokines, and noticeably reduced CRP, whereas it increased high-density lipoprotein cholesterol (HDLc) and improved endothelial function. Thus, consuming between 100 and 150 g/day of whole apples is associated with a lower CVD risk and decreases in blood pressure, pulse pressure, total cholesterol, low-density lipoprotein cholesterol, and inflammation status as well as with increases in HDLc and endothelial function. These results, support the regular consumption of whole apples as an aid in the prevention of CVD.
Is part ofCritical Reviews in Food Science and Nutrition, 2020, vol. 60, núm. 22, p. 3862-3875
European research projects
Except where otherwise noted, this item's license is described as cc-by-nc-nd, (c) Sandoval-Ramírez, Berner Andrée et al., 2020
Showing items related by title, author, creator and subject.
Gut microbiota profile and its association with clinical variables and dietary intake in overweight/obese and lean subjects: A cross-sectional study Companys, Judit; Gosalbes, Maria Jose; Pla-Paga, Laura; Calderon-Perez, Lorena; Llaurado, Elisabet; Pedret, Anna; Valls, Rosa Maria; Jiménez-Hernández, Núria; Sandoval-Ramírez, Berner Andree; del Bas, Josep Maria; Caimari, Antoni; Rubió Piqué, Laura; Solà, Rosa (MDPI, 2021-06)We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 ...
Calderón-Pérez, Lorena; Gosalbes, Maria José; Yuste, Silvia; Valls, Rosa M.; Pedret, Anna; Llauradó, Elisabet; Jimenez-Hernandez, Núria; Artacho, Alejandro; Pla-Pagà, Laura; Companys, Judit; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Rubió Piqué, Laura; Solà, Rosa (Springer Nature, 2020-04-15)Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive ...
Validation of dried blood spot cards to determine apple phenolic metabolites in human blood and plasma after an acute intake of red-fleshed apple snack Yuste, Silvia; Macià i Puig, Ma Alba; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Fernández Castillejo, Sara; Catalán Santos, Úrsula; Motilva Casado, Mª José; Rubió Piqué, Laura (Wiley, 2018)Scope: The application of dried blood spot (DBS) cards for the study in human blood of dietary polyphenol bioavailability has been poorly studied. Methods and results: An analytical method based on blood sampling with DBS ...