Association of BST-2 Gene Variants With HIV Disease Progression Underscores the Role of BST-2 in HIV Type 1 Infection
MetadataShow full item record
We tested bone marrow stromal cell antigen 2 (BST-2) gene variants rs3217318, a 19-base-pair insertion/deletion polymorphism in the promoter region, and rs10415893, a tag single-nucleotide polymorphism in the 3′ untranslated region, for their association with human immunodeﬁciency virus type 1 (HIV-1) infection and disease progression. The study included 356 subjects exposed to HIV-1 (185 with and 171 without infection) and 188 controls. The first decrease in the CD4+ T-cell count to <200 cells/µL was used as the primary outcome, whereas the primary outcome plus initiation of any antiretroviral treatment was used as a secondary composite outcome. Association with progression was found for both rs3217318 and rs10415893, following an overdominant model. Diplotype analysis revealed faster progression to both outcomes for subjects carrying the Δ19_G/i19_A diplotype. Luciferase assay showed that a promoter sequence containing the i19 allele had the lowest expression levels, suggesting that i19 allele carriers could have less BST-2 expression, reducing their capability to retain viral particles. These results point to the relevance of BST-2 as a host genetic factor modifying HIV-1 disease progression.
Is part ofJournal of Infectious Diseases, 2013, vol. 207, num. 3, p. 411-419
European research projects
Showing items related by title, author, creator and subject.
Herrero, Rocío; Real, Luis M.; Rivero-Juárez, Antonio; Pineda, Juan Antonio; Camacho, Ángela; Macías, Juan; Laplana Lafaja, Marina; Konieczny, Piotr; Márquez, Francisco J.; Souto, Juan Carlos; Soria, José Manuel; Saulle, Irma; Lo Caputo, Sergio; Biasin, Mara; Rivero, Antonio; Fibla Palazón, Joan; Caruz, Antonio (Springer Nature, 2015-03)HIV-1 induces activation of complement through the classical and lectin pathways. However, the virus incorporates several membrane-bound or soluble regulators of complement activation (RCA) that inactivate complement. HIV-1 ...
Genetic associations of the vitamin D and antiviral pathways with natural resistance to HIV-1 infection are influenced by interpopulation variability Aguilar-Jiménez, Wbeimar; Zapata, Wildeman; Rivero-Juárez, Antonio; Pineda, Juan Antonio; Laplana Lafaja, Marina; Taborda, Natalia A.; Biasin, Mara; Clerici, Mario; Caruz, Antonio; Fibla Palazón, Joan; Rugeles, Maía T. (Elsevier, 2019)Vitamin D (VitD) may modulate anti-HIV-1 responses modifying the risk to acquire the HIV-1-infection. We performed a nested case-control exploratory study involving 413 individuals; HIV-1-exposed seropositives (cases) and ...
Laplana Lafaja, Marina; Sánchez de la Torre, Manuel; Puig, Teresa; Caruz, Antonio; Fibla Palazón, Joan (Elsevier, 2014-04-21)Vitamin-D has pleiotropic effects on calcium and bone metabolism, cellular growth control, cell differentiation and modulation of both innate and acquired immune response. Previous studies revealed the association of ...