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dc.contributor.authorLaplana Lafaja, Marina
dc.contributor.authorRoyo Sánchez-Palencia, José Luis
dc.contributor.authorFibla Palazón, Joan
dc.date.accessioned2020-02-12T09:34:38Z
dc.date.available2020-02-12T09:34:38Z
dc.date.issued2018-08-01
dc.identifier.issn0378-1119
dc.identifier.urihttp://hdl.handle.net/10459.1/68000
dc.description.abstractIntroduction Vitamin-D plays a role regulating the immune response against to viral infection. In this sense, vitamin-D deficiency may confer increased susceptibility to enveloped virus infection such as HIV, Hepatitis, Dengue and Respiratory Syncytial virus infection, among others. Vitamin D activity is mediated by its receptor (VDR), which acts as a transcription factor modulating the expression of genes triggering the response against viruses. To date, six major VDR polymorphisms (Cdx, A1012G, FokI, BsmI, ApaI and TaqI) have been studied in the context of viral infection susceptibility. Reported studies show controversial results probably due to statistical lack of power and population genetic differences. Aims To do a systematic review of the published data and to perform a meta-analysis examining the role of six VDR polymorphisms on infection susceptibility to enveloped virus. Results From all markers and virus considered an association of FokI polymorphism with RSV infection emerges as significant. The worldwide distribution of risk T-allele reveals a lower prevalence in African populations that runs parallel with the relative lower incidence of RSV-associated severe ALRI in children <1 year described in African samples. Conclusion The results disclose FokI polymorphism as a relevant variant capturing the association of VDR polymorphisms with viral infection.
dc.description.sponsorshipML was recipient of a fellowship from the University of Lleida. This work was supported by grants to the University of Lleida (J.F. principal investigator) from Fondo de Investigación Sanitaria (FIS PI051778) and Ministerio de Ciencia e Innovación (CGL 2007-62875).
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relationMIECI/PN2004-2007/CGL-2007-62875
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.gene.2018.08.017
dc.relation.ispartofGene, 2018, vol. 678, p. 384-394
dc.rightscc-by-nc-nd, (c) Elsevier, 2018
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.subjectVitamin D receptor
dc.subjectPolymorphism
dc.subjectFokI
dc.subjectMeta-analysis
dc.subjectEnveloped virus
dc.titleVitamin D Receptor polymorphisms and risk of enveloped virus infection: a meta-analysis
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2020-02-12T09:34:38Z
dc.identifier.idgrec028161
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1016/j.gene.2018.08.017


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cc-by-nc-nd, (c) Elsevier, 2018
Except where otherwise noted, this item's license is described as cc-by-nc-nd, (c) Elsevier, 2018