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dc.contributor.authorHerrero, Rocío
dc.contributor.authorReal, Luis M.
dc.contributor.authorRivero-Juárez, Antonio
dc.contributor.authorPineda, Juan Antonio
dc.contributor.authorCamacho, Ángela
dc.contributor.authorMacías, Juan
dc.contributor.authorLaplana Lafaja, Marina
dc.contributor.authorKonieczny, Piotr
dc.contributor.authorMárquez, Francisco J.
dc.contributor.authorSouto, Juan Carlos
dc.contributor.authorSoria, José Manuel
dc.contributor.authorSaulle, Irma
dc.contributor.authorLo Caputo, Sergio
dc.contributor.authorBiasin, Mara
dc.contributor.authorRivero, Antonio
dc.contributor.authorFibla Palazón, Joan
dc.contributor.authorCaruz, Antonio
dc.date.accessioned2020-02-12T07:52:23Z
dc.date.available2020-02-12T07:52:23Z
dc.date.issued2015-03
dc.identifier.issn1466-4879
dc.identifier.urihttp://hdl.handle.net/10459.1/67997
dc.description.abstractHIV-1 induces activation of complement through the classical and lectin pathways. However, the virus incorporates several membrane-bound or soluble regulators of complement activation (RCA) that inactivate complement. HIV-1 can also use the complement receptors (CRs) for complement-mediated antibody-dependent enhancement of infection (Ć-ADE). We hypothesize that hypofunctional polymorphisms in RCA or CRs may protect from HIV-1 infection. For this purpose, 139 SNPs located in 19 RCA and CRs genes were genotyped in a population of 201 Spanish HIV-1-exposed seronegative individuals (HESN) and 250 HIV-1-infected patients. Two SNPs were associated with infection susceptibility, rs1567190 in CR2 (odds ratio (OR)=2.27, P=1 × 10-4) and rs2842704 in C4BPA (OR=2.11, P=2 × 10-4). To replicate this finding, we analyzed a cohort of Italian, sexually HESN individuals. Although not significant (P=0.25, OR=1.57), similar genotypic proportions were obtained for the CR2 marker rs1567190. The results of the two association analyses were combined through a random effect meta-analysis, with a significant P-value of 2.6x10-5 (OR=2.07). Furthermore, we found that the protective CR2 genotype is correlated with lower levels CR2 mRNA as well as differences in the ratio of the long and short CR2 isoforms.Genes and Immunity advance online publication, 8 January 2015; doi:10.1038/gene.2014.71.
dc.description.sponsorshipThis work was supported by Spanish Health Ministry [PI021476, PI051778 and PI10/01232 to JF, JAP and ACar]; Instituto de Salud Carlos III-RETIC [RD06/006 to JAP]; Fundació Marató TV3 [020730 and 020732 to JF and ACar]; Junta de Andalucía [PI-0335/2009 to ACar]; Fundación Progreso y Salud of the Consejería de Salud de la Junta de Andalucía [AI-0021 to JAP]; and Universidad de Jaen [UJA2013/10/03 to ACar].
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1038/gene.2014.71
dc.relation.ispartofGenes and Immunity, 2015, vol. 16, p. 134-141
dc.rights(c) Herrero, Rocío et al., 2015
dc.subjectHIV infection
dc.subjectgenetica asociación
dc.subjectgenes complemento
dc.titleAssociation of complement receptor 2 polymorphisms withinnate resistance to HIV-1 infection
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2020-02-12T07:52:23Z
dc.identifier.idgrec022124
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1038/gene.2014.71


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