Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project
López Cano, Carolina
MetadataShow full item record
BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the total plaque area in the prediabetes stage. METHODS: Atheromatous plaque burden (quantity of plaques and total plaque area) was assessed in 12 territories from the carotid and femoral regions using ultrasonography in 6688 non-diabetic middle-aged subjects without cardiovascular disease. Prediabetes was defined by glycosylated hemoglobin (HbA1c) between 5.7 and 6.4% according to the American Diabetes Association guidelines. RESULTS: Prediabetes was diagnosed in 33.9% (n = 2269) of the ILERVAS participants. Subjects with prediabetes presented a higher prevalence of subclinical atheromatous disease than participants with HbA1c < 5.7% (70.4 vs. 67.5%, p = 0.017). In the population with prediabetes this was observed at the level of the carotid territory (p < 0.001), but not in the femoral arteries. Participants in the prediabetes stage also presented a significantly higher number of affected territories (2 [1;3] vs. 1 [0;3], p = 0.002), with a positive correlation between HbA1c levels and the number of affected territories (r = 0.068, p < 0.001). However, atheromatosis was only significantly (p = 0.016) magnified by prediabetes in those subjects with 3 or more cardiovascular risk factors. The multivariable logistic regression model showed that the well-established cardiovascular risk factors together with HbA1c were independently associated with the presence of atheromatous disease in participants with prediabetes. When males and females were analyzed separately, we found that only men with prediabetes presented both carotid and femoral atherosclerosis, as well as an increase of total plaque area in comparison with non-prediabetic subjects. CONCLUSIONS: The prediabetes stage is accompanied by an increased subclinical atheromatous disease only in the presence of other cardiovascular risk factors. Prediabetes modulates the atherogenic effect of cardiovascular risk factors in terms of distribution and total plaque area in a sex-dependent manner. Trial registration NCT03228459 (clinicaltrials.gov).
Is part ofCardiovascular Diabetology, 2019, vol. 18, núm. 1: 154, p. 1-12
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Sánchez Peña, Enric et al., 2019
Showing items related by title, author, creator and subject.
Dissimilar impact of Mediterranean diet and physical activity on estimated body composition: A cross-sectional study from the ILERVAS project Sánchez, Marta; Sánchez Peña, Enric; Hernández García, Marta; González, Jessica; Purroy Garcia, Francisco; Rius, Ferran; Pamplona Gras, Reinald; Farràs-Sallés, Cristina; Gutiérrez Carrasquilla, Liliana; Fernández i Giráldez, Elvira; Bermúdez López, Marcelino; Salvador, Javier; Salas-Salvadó, Jordi; Lecube Torelló, Albert (MDPI, 2019-06-17)There is a close relationship between lifestyle behaviors and excess adiposity. Althoughbody mass index (BMI) is the most used approach to estimate excess weight, other anthropometricindices have been developed to ...
Effects of Mediterranean Diet and Physical Activity on Pulmonary Function: A Cross-Sectional Analysis in the ILERVAS Project Gutiérrez Carrasquilla, Liliana; Sánchez Peña, Enric; Hernández García, Marta; Polanco, Dinora; Salas-Salvadó, Jordi; Betriu i Bars, M. Àngels; Gaeta, Anna Michela; Carmona, Paola; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Farràs-Sallés, Cristina; López Cano, Carolina; Fernández i Giráldez, Elvira; Lecube Torelló, Albert (MDPI, 2019)A few studies showed that both adherence to Mediterranean diet (MedDiet) and physical activity practice have a positive impact on pulmonary function in subjects with lung disease. These associations are not well studied ...
Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort Sánchez, Marta; Sánchez Peña, Enric; Bermúdez López, Marcelino; Torres, Gerard; Farràs-Sallés, Cristina; Pamplona Gras, Reinald; Castro-Boqué, Eva; Valdivielso Revilla, José Manuel; Purroy Garcia, Francisco; Martínez Alonso, Montserrat; Godoy i García, Pere; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Hernández García, Marta; Rius, Ferran; Lecube Torelló, Albert (MDPI, 2021-03-23)Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. ...