The lipid type affects the in vitro digestibility and β-carotene bioaccessibility of liquid or solid lipid nanoparticles
Data de publicació2019-12-13
de Abreu Martins, Helena
Hilsdorf Piccoli, Roberta
MetadadesMostra el registre d'unitat complet
olid lipid nanoparticles (SLNs) are emulsion-based carriers of lipophilic bioactive compounds. However, their digestibility may be affected by the solid lipid phase composition. Hence, the aim of this work was to study the in vitro lipolysis kinetics as well as the relationship between the lipid digestion, micelle fraction composition and β-carotene bioaccessibility of SLNs with different solid lipids, being blends of medium chain triglyceride (MCT) oil, glyceryl stearate (GS) or hydrogenated palm oil (HPO) as compared to liquid lipid nanoparticles (LLNs) with pure MCT. SLNs formulated with GS were fully digested, similarly to LLNs. However, HPO-containing SLNs presented slower lipolysis kinetics during the intestinal phase at increasing HPO concentration. Despite this, HPO-SLNs showed higher β-carotene bioaccessibility, which was related to the higher amount of monounstaturated free fatty acids in the micelle fraction. Thus, this work provides valuable insight for designing delivery systems of bioactive compounds with optimal functionality.
És part deFood Chemistry, 2020, vol. 311, article number 126024
Projectes de recerca europeus
Els fitxers de llicència següents estan associats amb aquest element:
Mostrant elements relacionats per títol, autor i matèria.
Artiga Artigas, María; Montoliu Boneu, Júlia; Salvia Trujillo, Laura; Martín Belloso, Olga (Elsevier, 2019-10-05)Highly concentrated (HC) emulsions and or submicron emulsions arise as an interesting strategy to encapsulate and transport labile lipophilic bioactive compounds such as curcumin to be further incorporated into food ...
Influence of essential oils and pectin on nanoemulsion formulation: A ternary phase experimental approach Artiga Artigas, María; Guerra-Rosas, María Inés; Morales-Castro, Juliana; Salvia Trujillo, Laura; Martín Belloso, Olga (Elsevier, 2018)A pseudo-ternary phase experimental approach was used to model the influence of the mixture components concentration on the nanoemulsions properties as ternary systems. For this, several types of essential oils (EO) were ...
Formation of Double (W1/O/W2) Emulsions as Carriers of Hydrophilic and Lipophilic Active Compounds Artiga Artigas, María; Molet Rodríguez, Anna; Salvia Trujillo, Laura; Martín Belloso, Olga (Springer, 2018)This work aimed at obtaining an optimized formation procedure of water-in-oil-in-water (W1/O/W2) double emulsions as potential templates to carry hydrophilic (e.g., chlorophyllin; CHL) and/or hydrophobic (e.g., lemongrass ...