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dc.contributor.authorFalguera, Mireia
dc.contributor.authorVilanova Fillat, María Belén
dc.contributor.authorAlcubierre Calvo, Núria
dc.contributor.authorGranado Casas, Minerva
dc.contributor.authorMarsal Mora, Josep Ramon
dc.contributor.authorMiró, Neus
dc.contributor.authorCebrian, Cristina
dc.contributor.authorMolló Inesta, Àngels
dc.contributor.authorFranch-Nadal, Josep
dc.contributor.authorMata Cases, Manel
dc.contributor.authorCastelblanco Echavarría, Esmeralda
dc.contributor.authorMauricio Puente, Dídac
dc.date.accessioned2020-01-22T13:38:17Z
dc.date.available2020-01-22T13:38:17Z
dc.date.issued2020-01-07
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/10459.1/67852
dc.description.abstractObjectives: To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects with pre-diabetes. Design: Prospective observational cohort study. Setting: General population from a semi-rural area. Participants: The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014. Results: The prevalence of undiagnosed diabetes was 20, 3.4% (95% CI 2.6 to 4.2) and that of pre-diabetes was 229, 39.3% (37.3 to 41.3). Among those with pre-diabetes, 18.3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to <126 mg/dL), 58.1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5.7 to <6.5) and 23.6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41.6%(37.8 to 45.4) returned to normoglycaemia, 57.6% (57.8 to 61.4) persisted in pre-diabetes and 0.6% (0 to 1.2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1.033; 1.011 to 1.056), higher physical activity (0.546; 0.360 to 0.827), body mass index (1.121; 1.029 to 1.222) and a family history of diabetes (1.543; 1.025 to 2.323). The variables significantly associated with glycaemic normalisation were older age (0.948; 0.916 to 0.982) and body mass index (0.779; 0.651 to 0.931). Conclusions: Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3.4% and that of pre-diabetes was 39.3%. After a 1-year follow-up, a small proportion of subjects (0.6%) with pre-diabetes progressed to diabetes, while a high proportion (41.6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass index
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBMJ
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1136/bmjopen-2019-033332
dc.relation.ispartofBmj Open, 2020, vol. 10, num. 1, p. 1-9
dc.rightscc-by-nc (c) Falguera, Mireia et al., 2020
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titlePrevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2020-01-22T13:38:17Z
dc.identifier.idgrec029693
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2019-033332


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cc-by-nc (c) Falguera, Mireia et al., 2020
Except where otherwise noted, this item's license is described as cc-by-nc (c) Falguera, Mireia et al., 2020