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dc.contributor.authorGomes, Andreia
dc.contributor.authorOudot, Carole
dc.contributor.authorMacià i Puig, Ma Alba
dc.contributor.authorFoito, Alexandre
dc.contributor.authorCarregosa, Diogo
dc.contributor.authorStewart, Derek
dc.contributor.authorWiele, Tom van de
dc.contributor.authorBerry, David
dc.contributor.authorMotilva Casado, Mª José
dc.contributor.authorBrenner, Catherine
dc.contributor.authorNunes dos Santos, Cláudia
dc.description.abstractDiets rich in (poly)phenols are associated with a reduced reduction in the incidence of cardiovascular disorders. While the absorption and metabolism of (poly)phenols has been described, it is not clear how their metabolic fate is affected under pathological conditions. This study evaluated the metabolic fate of berry (poly)phenols in an in vivo model of hypertension as well as the associated microbiota response. Dahl salt-sensitive rats were fed either a low-salt diet (0.26% NaCl) or a high-salt diet (8% NaCl), with or without a berry mixture (blueberries, blackberries, raspberries, Portuguese crowberry and strawberry tree fruit) for 9 weeks. The salt-enriched diet promoted an increase in the urinary excretion of berry (poly)phenol metabolites, while the abundance of these metabolites decreased in faeces, as revealed by UPLC–MS/MS. Moreover, salt and berries modulated gut microbiota composition as demonstrated by 16S rRNA analysis. Some changes in the microbiota composition were associated with the high-salt diet and revealed an expansion of the families Proteobacteria and Erysipelotrichaceae. However, this effect was mitigated by the dietary supplementation with berries. Alterations in the metabolic fate of (poly)phenols occur in parallel with the modulation of gut microbiota in hypertensive rats. Thus, beneficial effects of (poly)phenols could be related with these interlinked modifications, between metabolites and microbiota environments.ca_ES
dc.description.sponsorshipC.B., C.N.d.S., C.O. were funded by ANR (ANR-13-ISV1-0001-01) and FCT (FCTANR/BEX-BCM/0001/2013). D.B. was funded by the Austrian Science Fund (FWF P26127-B20) and European Research Council (Starting Grant: FunKeyGut 741623). D.S. and A.F. acknowledge support from Scottish Government: Rural and Environment Science and Analytical Services. We also acknowledge the Investment for the Future program ANR-11-IDEX-0003-01 within the LABEX ANR-10-LABX-0033 (C.B., C.O.), Fundação para a Ciência e Tecnologia financial support of A.G. (SFRH/BD/103155/2014) and C.N.d.S. (IF/01097/2013). iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is cofounded by FCT through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged.ca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofNutrients, 2019, vol. 11, núm. 11, article number 2634ca_ES
dc.rightscc-by (c) Gomes et al., 2019ca_ES
dc.subjectGut metabolismca_ES
dc.subjectHigh salt intakeca_ES
dc.titleBerry-enriched diet in salt-sensitive hypertensive rats: metabolic fate of (poly)phenols and the role of gut microbiotaca_ES

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