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dc.contributor.authorServià Goixart, Lluís
dc.contributor.authorJové Font, Mariona
dc.contributor.authorSol, Joaquim
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorBadia Castello, Mariona
dc.contributor.authorMontserrat, Neus
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorTrujillano Cabello, Javier
dc.date.accessioned2019-12-20T10:38:02Z
dc.date.available2019-12-20T10:38:02Z
dc.date.issued2019-05-22
dc.identifier.issn1757-7241
dc.identifier.urihttp://hdl.handle.net/10459.1/67764
dc.description.abstractBackground: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established by liquid chromatography coupled to mass spectrometry, in patients allocated to an intensive care unit (in the University Hospital Arnau de Vilanova, Lleida, Spain) in the first hours after a severe trauma (n = 48). Univariate and multivariate statistics were employed to establish potential predictors of mortality. Results: Plasma of patients non surviving to trauma (n = 5) exhibited a discriminating metabolomic pattern, involving basically metabolites belonging to fatty acid and catecholamine synthesis as well as tryptophan degradation pathways. Thus, concentration of several metabolites exhibited an area under the receiver operating curve (ROC) higher than 0.84, including 3-indolelactic acid, hydroxyisovaleric acid, phenylethanolamine, cortisol, epinephrine and myristic acid. Multivariate binary regression logistic revealed that patients with higher myristic acid concentrations had a non-survival odds ratio of 2.1 (CI 95% 1.1–3.9). Conclusions: Specific fatty acids, catecholamine synthesis and tryptophan degradation pathways could be implicated in a negative outcome after trauma. The metabolomic study of severe trauma patients could be helpful for biomarker proposal.ca_ES
dc.description.sponsorshipThis work has been partially supported by the IRBLleida biobank and RETICS BIOBANCOS RD09/0076/00059, the Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III (PI 17–00134) and the Generalitat of Catalonia (2017SGR969). FEDER Funds are also acknowledged: “A way to make Europe”. MJ is a professor under the Serra Hunter program (Generalitat de Catalunya).
dc.language.isoengca_ES
dc.publisherBMC (part of Springer Nature)ca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1186/s13049-019-0631-5ca_ES
dc.relation.ispartofScandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019, vol. 27, núm. 56ca_ES
dc.rightscc-by (c) Servià et al., 2019ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMetabolomeca_ES
dc.subjectMortalityca_ES
dc.subjectTraumatic brain injuryca_ES
dc.subjectBiomarkerca_ES
dc.subjectMultiple traumatismca_ES
dc.titleA prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe traumaca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec028808
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1186/s13049-019-0631-5


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