A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma
MetadataShow full item record
Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established by liquid chromatography coupled to mass spectrometry, in patients allocated
to an intensive care unit (in the University Hospital Arnau de Vilanova, Lleida, Spain) in the first hours after a severe trauma (n = 48). Univariate and multivariate statistics were employed to establish potential predictors of mortality. Results: Plasma of patients non surviving to trauma (n = 5) exhibited a discriminating metabolomic pattern, involving basically metabolites belonging to fatty acid and catecholamine synthesis as well as tryptophan degradation pathways. Thus, concentration of several metabolites exhibited an area under the receiver operating curve (ROC) higher than 0.84, including 3-indolelactic acid, hydroxyisovaleric acid, phenylethanolamine, cortisol, epinephrine and myristic acid. Multivariate binary regression logistic revealed that patients with higher myristic acid concentrations had a non-survival odds ratio of 2.1 (CI 95% 1.1–3.9). Conclusions: Specific fatty acids, catecholamine synthesis and tryptophan degradation pathways could be implicated in a negative outcome after trauma. The metabolomic study of severe trauma patients could be helpful for biomarker proposal.
Is part ofScandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019, vol. 27, núm. 56
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Servià Goixart, Lluís; Serrano Casasola, José Carlos Enrique; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (Public Library of Science, 2018)Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. ...
Plasma antioxidant capacity in critical polytraumatized patients?: methods, severity, and anatomic location Servià Goixart, Lluís; Trujillano Cabello, Javier; Serrano Casasola, José Carlos Enrique; Pamplona Gras, Reinald; Badia Castello, Mariona; Jové Font, Mariona; Justes, Margarida; Domingo, Joana; Portero Otín, Manuel (BioMed Central, 2014)
Classification of dermatological disorders in critical care patients: a prospective observational study Badia Castello, Mariona; Servià Goixart, Lluís; Casanova i Seuma, Josep M. (Josep Manel); Montserrat, Neus; Vilanova, Judit; Vicario, Esther; Rodriguez, Angel; Trujillano Cabello, Javier (Elsevier, 2013)Purpose: The objective of this study was to identify dermatological disorders detected in the intensive care unit (ICU), to analyze their specific characteristics, and to define a useful classification for intensive care ...