Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
Castagnini, Juan Manuel
Quifer Rada, Paola
Lamuela Raventós, Rosa Ma.
Marrero González, Pedro F.
MetadataShow full item record
Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A–stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.
Is part ofAntioxidants, 2019, vol. 8, núm. 9, article number 360
European research projects
Showing items related by title, author, creator and subject.
Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study Sánchez Peña, Enric; Mizab, Chadia; Sauret, Ariadna; Barbé Illa, Ferran; Martí, Raquel; López Cano, Carolina; Hernández García, Marta; Gutiérrez Carrasquilla, Liliana; Carmona, Paola; González, Jessica; Dalmases, Mireia; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2020)In order to compare spirometric maneuvers in adults according to the presence of type 1 diabetes, a case-control study including 75 patients with type 1 diabetes and 75 controls matched by sex, age, and body mass index ...
Jové Font, Mariona; Tibau, Joan; Serrano Casasola, José Carlos Enrique; Berdún Hernández, Rebeca; Rodríguez Palmero, María; Font-i-Furnols, Maria; Cassanyé, Anna; Rodriguez Mortera, Reyna; Sol, Joaquim; Rassendren, Helene; Fàbrega, Emma; Crescenti, Anna; Castell, Anna; Sabater, Mónica; Ortega, Francisco J.; Martín Garí, Meritxell; Quintanilla Aguado, Raquel; Puigjaner, Joaquim; Moreno, José Antonio; Prat, Joan; Arola i Ferrer, Lluís; Fernández Real, José Manuel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2020-09-01)As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed ...
Hepatic and Visceral Adipose Tissue 11bHSD1 Expressions are Markers of Body Weight Loss After Bariatric Surgery Pardina, Eva; Baena-Fustegueras, Juan A; Fort, José Manuel; Ferrer, Roser; Rossell, Joana; Esteve, Montserrat; Peinado Onsurbe, Julia; Grasa, Mar (Wiley online library, 2015)Cortisolemia and 11βHSD1 in liver and adipose tissue are altered in obesity. However, their participation in the development of obesity remains unclear. This study analyzed these parameters in the transition from morbid ...