Purpose: The principal aim of the review is to study the evidence regarding the effectiveness of diacutaneous Fibrolysis (DF) in musculoskeletal diseases and getting some recommendations evidences based. Methods: An electronic literature search was conducted utilizing PubMed, ScienceDirect, PEDRO, Cochrane and Mendeley. All titles and abstracts were reviewed, and full text articles meeting eligibility criteria were assessed in detail to determine inclusion or exclusion. Articles were reviewed by two different investigators. Results: Principal findings of this review shows an improvement in functional capacity and a significant reduction of symptoms in the FD groups, immediately after intervention and at least, three months follow up. Conclusions: There is limited evidence and more studies are needed to assess the effectiveness of DF to improve the function or the symptomatology.