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dc.contributor.authorFarràs, Marta
dc.contributor.authorArranz, Sara
dc.contributor.authorCarrión Bolorino, Silvia
dc.contributor.authorSubirana Cachinero, Isaac
dc.contributor.authorMuñoz-Aguayo, Daniel
dc.contributor.authorBlanchart, Gemma
dc.contributor.authorKool, Marjon
dc.contributor.authorSolà, Rosa
dc.contributor.authorMotilva Casado, Mª José
dc.contributor.authorEscolà Gil, Joan Carles
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorFernández Castillejo, Sara
dc.contributor.authorPedret, Anna
dc.contributor.authorEstruch Riba, Ramon
dc.contributor.authorCovas Planells, María Isabel
dc.contributor.authorFitó, Montserrat
dc.contributor.authorHernáez Camba, Álvaro
dc.contributor.authorCastañer, Olga
dc.date.accessioned2019-11-19T12:02:21Z
dc.date.available2019-11-19T12:02:21Z
dc.date.issued2019
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10459.1/67574
dc.description.abstractThe consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (p = 0.041 and p = 0.053, versus baseline and the control intervention, respectively), CAV1 (p = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (p = 0.005, p = 0.005, and p = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes.
dc.description.sponsorshipThis research was funded by: the Spanish Ministry of Economy and Competitiveness (AGL2009-13517-C03-01, AGL2012-40144-C03-01), the Instituto de Salud Carlos III (CB06/03/0028, CB07/08/0016, CD17/00122, CD17/00233, and JR17/00022), FEDER funds (CB06/03), and the Agència de Gestió d’Ajuts Universitaris i de Recerca (2014-SGR-240, 2017-SGR-522).
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI
dc.relationMICINN/PN2008-2011/AGL2009-13517-C03-01
dc.relationMICINN/PN2008-2011/AGL2012-40114-C03-01
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/nu11081732
dc.relation.ispartofNutrients, 2019, vol. 11, num. 8, p. 1732
dc.rightscc-by (c) Farràs, Marta et al., 2019
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFunctional virgin olive oil
dc.subjectOlive oil phenolic compounds
dc.subjectThyme phenolic compounds
dc.subjectCholesterol efflux
dc.subjectTranscriptomics
dc.titleA functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: A randomized, crossover, controlled trial
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2019-11-19T12:02:21Z
dc.identifier.idgrec029202
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.3390/nu11081732


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cc-by (c) Farràs, Marta et al., 2019
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