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dc.contributor.authorLang, Andreas
dc.contributor.authorLee, Marina S.
dc.contributor.authorDolek, Matthias
dc.contributor.authorBerchtold, Julitta
dc.contributor.authorOtto, Mathias
dc.date.accessioned2019-11-12T11:50:11Z
dc.date.available2019-11-12T11:50:11Z
dc.date.issued2019-06-21
dc.identifier.issn2190-4715
dc.identifier.urihttp://hdl.handle.net/10459.1/67536
dc.description.abstractBackground and approach Common standards for laboratory studies of non-target organisms are recognised as prerequisite to assist the risk assessments regarding the evaluation of environmental effects of transgenic crops. Here, we provide specific recommendations significant for experimental procedures of laboratory studies to test potential adverse effects of Bt maize on larvae of non-target Lepidoptera. We searched and analysed both ecotoxicological test protocols for pesticides in the EU as well as the non-target tests with Lepidoptera applied in unpublished industry studies submitted officially by agro-companies for the GMO authorisation in Europe. Results The classical ecotoxicology protocols applied for testing pesticides could serve as general guidelines, but do not completely fit the specific and differing requirements for assessing non-target effects of transgenic crops. The analysis of the non-target studies submitted for the application of the cultivation of Bt maize in Europe revealed critical limitations, thus corroborating the urgent need for common quality criteria. Based on our evaluations, we identified several issues requiring harmonisation or standardisation of the experimental conditions and approach, e.g., the application of Bt maize pollen, synthetic toxins, the provided diet for larvae, experimental controls, magnitude and duration of exposure to Bt, relevant variables to be recorded, and sufficient statistical power. Conclusions Our recommendations should stimulate the development of precise guidance for the authorities, and support the operationalisation of the required laboratory tests for the evaluation of non-target effects of Bt maize pollen on non-target Lepidoptera, also contributing to standards of other ecotoxicity tests with Lepidoptera larvae, e.g., for pesticides.ca_ES
dc.description.sponsorshipThis article has been prepared as an outcome of the BfN research project “Basisdaten zur Effektbewertung verschiedener Bt-Toxine auf Schmetterlingslarven” (FKZ 3515890100).ca_ES
dc.language.isoengca_ES
dc.publisherSpringer Natureca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1186/s12302-019-0220-2ca_ES
dc.relation.ispartofEnvironmental Sciences Europe, 2019, vol. 31, article number 39ca_ES
dc.rightscc-by (c) Lang et al., 2019ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTransgenic cropsca_ES
dc.subjectEnvironmental risk assessmentca_ES
dc.subjectNon-target effectsca_ES
dc.subjectLepidopteraca_ES
dc.titleLaboratory tests with Lepidoptera to assess non-target effects of Bt maize pollen: analysis of current studies and recommendations for a standardised designca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1186/s12302-019-0220-2


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