Mitochondrial calcium signaling and neurodegenerative diseases

View/ Open
Issue date
2018-11-16Suggested citation
Britti, Elena;
Delaspre, Fabien;
Tamarit Sumalla, Jordi;
Ros Salvador, Joaquim;
.
(2018)
.
Mitochondrial calcium signaling and neurodegenerative diseases.
Neuronal signaling, 2018, vol. 2, núm. 4, p. NS20180061.
https://doi.org/10.1042/NS20180061.
Metadata
Show full item recordAbstract
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).
Is part of
Neuronal signaling, 2018, vol. 2, núm. 4, p. NS20180061European research projects
Collections
Except where otherwise noted, this item's license is described as cc-by (c) Elena Britti et al., 2018
Related items
Showing items related by title, author, creator and subject.
-
Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment
Britti, Elena; Delaspre, Fabien; Feldman, Anat; Osborne, Melissa; Greif, Hagar; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Wiley Open Access, 2018)Friedreich ataxia (FA) is a rare disease caused by deficiency of frataxin, a mitochondrial protein. As there is no cure available for this disease, many strategies have been developed to reduce the deleterious effects of ... -
Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes
Rodríguez-Manzaneque Martínez, María Teresa; Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Ros Salvador, Joaquim; Herrero Perpiñán, Enrique (American Society for Cell Biology, 2002)Yeast cells contain a family of three monothiol glutaredoxins: Grx3, 4, and 5. Absence of Grx5 leads to constitutive oxidative damage, exacerbating that caused by external oxidants. Phenotypic defects associated with the ... -
The Forkhead Transcription Factor Hcm1 Promotes Mitochondrial Biogenesis and Stress Resistance in Yeast
Rodríguez Colman, Maria José; Reverter Branchat, Gemma; Sorolla Bardají, Maria Alba; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (American Society for Biochemistry and Molecular Biology, 2010)In Saccharomyces cerevisiae, the forkhead transcription factor Hcm1 is involved in chromosome segregation, spindle pole dynamics, and budding. We found that Hcm1 interacts with the histone deacetylase Sir2 and shifts ...