Mitochondrial calcium signaling and neurodegenerative diseases

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Issue date
2018-11-16
Author
Britti, Elena
Delaspre, Fabien
Tamarit Sumalla, Jordi
Ros Salvador, Joaquim
Suggested citation
Britti, Elena; Delaspre, Fabien; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; . (2018) . Mitochondrial calcium signaling and neurodegenerative diseases. Neuronal signaling, 2018, vol. 2, núm. 4, p. NS20180061. https://doi.org/10.1042/NS20180061.
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Abstract
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).
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http://hdl.handle.net/10459.1/67520
DOI
https://doi.org/10.1042/NS20180061
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Neuronal signaling, 2018, vol. 2, núm. 4, p. NS20180061
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cc-by (c) Elena Britti et al., 2018
Except where otherwise noted, this item's license is described as cc-by (c) Elena Britti et al., 2018