A genomewide association study in divergently selected lines in rabbits reveals novel genomic regions associated with litter size traits
Sosa‐Madrid, Bolívar Samuel
Santacreu, María Antonia
MetadataShow full item record
Uterine capacity (UC), defined as the total number of kits from unilaterally ovariectomized does at birth, has a high genetic correlation with litter size. The aim of our research was to identify genomic regions associated with litter size traits through a genomewide association study using rabbits from a divergent selection experiment for UC. A high‐density SNP array (200K) was used to genotype 181 does from a control population, high and low UC lines. Traits included total number born (TNB), number born alive (NBA), number born dead, ovulation rate (OR), implanted embryos (IE) and embryo, foetal and prenatal survivals at second parity. We implemented the Bayes B method and the associations were tested by Bayes factors and the percentage of genomic variance (GV) explained by windows. Different genomic regions associated with TNB, NBA, IE and OR were found. These regions explained 7.36%, 1.27%, 15.87% and 3.95% of GV, respectively. Two consecutive windows on chromosome 17 were associated with TNB, NBA and IE. This genomic region accounted for 6.32% of GV of TNB. In this region, we found the BMP4, PTDGR, PTGER2, STYX and CDKN3 candidate genes which presented functional annotations linked to some reproductive processes. Our findings suggest that a genomic region on chromosome 17 has an important effect on litter size traits. However, further analyses are needed to validate this region in other maternal rabbit lines.
Is part ofJournal of Animal Breeding and Genetics-Zeitschrift für Tierzuchtung und Zuchtungsbiologie, 2020, vol. 137, núm. 2, p. 123-138
European research projects
Showing items related by title, author, creator and subject.
Sosa‐Madrid, Bolívar Samuel; Hernández, Pilar; Blasco, Agustín; Haley, Chris; Fontanesi, Luca; Santacreu, María Antonia; Pena i Subirà, Ramona Natacha; Navarro, Pau; Ibáñez-Escriche, N. (Wiley, 2019-11-07)Intramuscular fat (IMF) is one of the main meat quality traits for breeding programmes in livestock species. The main objective of this study was to identify genomic regions associated with IMF content comparing two rabbit ...
Genome-Wide Association Study Singles Out SCD and LEPR as the Two Main Loci Influencing Intramuscular Fat Content and Fatty Acid Composition in Duroc Pigs Ros Freixedes, Roger; Gol, Sofia; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Ibañez Escriche, Noelia; Dekkers, Jack C. M.; Estany Illa, Joan (Public Library of Science, 2016)Intramuscular fat (IMF) content and fatty acid composition affect the organoleptic quality and nutritional value of pork. A genome-wide association study was performed on 138 Duroc pigs genotyped with a 60k SNP chip to ...
Identification of functional mutations associated with environmental variance of litter size in rabbits Casto-Rebollo, Cristina; Argente, María José; García, María Luz; Pena i Subirà, Ramona Natacha; Ibáñez-Escriche, N. (BMC, 2020-05-06)Background: Environmental variance (VE) is partly under genetic control and has recently been proposed as a measure of resilience. Unravelling the genetic background of the VE of complex traits could help to improve ...