Linoleic acid metabolic pathway allows for an efficient increase of intramuscular fat content in pigs
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Background: Intramuscular fat (IMF) content is a relevant trait for high-quality meat products such as dry-cured ham, but increasing IMF has the undesirable correlated effect of decreasing lean growth. Thus, there is a need to find selection criteria for IMF independent from lean growth. In pigs, the proportion of linoleic (C18:2) and arachidonic (C20:4) acids decline with fat deposition and therefore they can be considered as indicators of fatness. The aim of this research was to estimate the genetic variation for C18:2 and C20:4 in IMF and their genetic correlations with IMF and lean growth traits, with the objective to assess their potential as specific biomarkers of IMF. The analysis was conducted using a full-pedigreed Duroc resource line with 91,448 records of body weight and backfat thickness (BT) at 180 days of age and 1371 records of fatty acid composition in the muscle gluteus medius. Results: The heritability estimates for C18:2 and C20:4 in IMF, whether expressed in absolute (mg/g of muscle) or in relative (mg/g of fatty acid) terms, as well as for their ratio (C20:4/C18:2), were high (> 0.40), revealing that the C18:2 to C20:4 pathway is subjected to substantial genetic influence. Litter effects were not negligible, with values ranging from 8% to 15% of the phenotypic variance. The genetic correlations of C18:2 and C20:4 with IMF and BT were negative (− 0.75 to − 0.66, for IMF, and − 0.64 to − 0.36, for BT), if expressed in relative values, but almost null (− 0.04 to 0.07), if expressed in absolute values, except for C18:2 with IMF, which was highly positive (0.88). The ratio of C20:4 to C18:2 also displayed a stronger genetic correlation with IMF (− 0.59) than with BT (− 0.10). Conclusions: The amount of C18:2 in muscle can be used as an IMF-specific biomarker. Selection for the absolute amount of C18:2 is expected to deliver a similar response outcome as selection for IMF at restrained BT. Further genetic analysis of the C18:2 metabolic pathway may provide new insights into differential fat deposition among adipose tissues and on candidate genes for molecular markers targeting specifically for one of them.
Is part ofJournal of Animal Science and Biotechnology, 2019, vol. 10, núm. 1, article number 33
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Tor i Naudí, Marc; Vilaró, Francisca; Ros Freixedes, Roger; Álvarez Rodríguez, Javier; Bosch Puig, Lluís; Gol, Sofia; Pena i Subirà, Ramona Natacha; Reixach, Josep; Estany Illa, Joan (MDPI, 2021-02-03)Circulating non-esterified fatty acids (NEFA) can reflect the composition of dietary fat or adipose tissues depending on the fasting conditions. Therefore, circulating NEFA may be valuable as biomarkers for meat quality ...
The effect of SCD and LEPR genetic polymorphisms on fat content and composition is maintained throughout fattening in Duroc pigs Henriquez Rodriguez, Eliana; Bosch, L.; Tor i Naudí, Marc; Pena i Subirà, Ramona Natacha; Estany Illa, Joan (Elsevier, 2016)The effects of the stearoyl-CoA desaturase (SCD; AY487830:g.2228T > C) and leptin receptor (LEPR; NM_001024587:g.1987C > T) polymorphisms on fat content and fatty acid (FA) composition were investigated throughout fattening. ...
Comparing the mRNA expression profile and the genetic determinism of intramuscular fat traits in the porcine gluteus medius and longissimus dorsi muscles González-Prendes, Rayner; Quintanilla Aguado, Raquel; Mármol-Sánchez, Emilio; Pena i Subirà, Ramona Natacha; Ballester, Maria; Figueiredo Cardoso, Tainã; Manunza, Arianna; Casellas, Joaquim; Cánovas, Angela; Díaz, Isabel; Noguera Jiménez, José Luis; Castelló, Anna; Mercadé Carceller, Anna; Amills i Eras, Marcel (BMC (part of Springer Nature), 2019-03-04)Background: Intramuscular fat (IMF) content and composition have a strong impact on the nutritional and organoleptic properties of porcine meat. The goal of the current work was to compare the patterns of gene expression ...