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dc.contributor.authorMontaner Tarbes, Sergio Roberto
dc.contributor.authorPortillo Obando, Hernando A. del
dc.contributor.authorMontoya, María
dc.contributor.authorFraile Sauce, Lorenzo José
dc.description.abstractThe porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important swine diseases in the world. It is causing an enormous economic burden due to reproductive failure in sows and a complex respiratory syndrome in pigs of all ages, with mortality varying from 2 to 100% in the most extreme cases of emergent highly pathogenic strains. PRRSV displays complex interactions with the immune system and a high mutation rate, making the development, and implementation of control strategies a major challenge. In this review, the biology of the virus will be addressed focusing on newly discovered functions of non-structural proteins and novel dissemination mechanisms. Secondly, the role of different cell types and viral proteins will be reviewed in natural and vaccine-induced immune response together with the role of different immune evasion mechanisms focusing on those gaps of knowledge that are critical to generate more efficacious vaccines. Finally, novel strategies for antigen discovery and vaccine development will be discussed, in particular the use of exosomes (extracellular vesicles of endocytic origin). As nanocarriers of lipids, proteins and nucleic acids, exosomes have potential effects on cell activation, modulation of immune responses and antigen presentation. Thus, representing a novel vaccination approach against this devastating disease.ca_ES
dc.description.sponsorshipSM-T is an industrial doctorate awarded by the Government of Catalonia, Spain (No. 2014 DI 044). This review received support from the FEDER project (COMRDI16-1-0035-03).ca_ES
dc.publisherFrontiers Mediaca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofFrontiers in Veterinary Science, 2019, vol. 6, article 38, 15 ppca_ES
dc.rightscc-by (c) Sergio Montaner-Tarbes et al., 2019ca_ES
dc.subjectPorcine reproductive and respiratory syndrome virusca_ES
dc.subjectVirus biologyca_ES
dc.subjectExtracellular vesiclesca_ES
dc.titleKey Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)ca_ES

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cc-by (c) Sergio Montaner-Tarbes et al., 2019
Except where otherwise noted, this item's license is described as cc-by (c) Sergio Montaner-Tarbes et al., 2019